The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
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IRS1-independent defects define major nodes of insulin resistancePhosphoinositides: Key modulators of energy metabolismLoss-of-Function Mutations in APPL1 in Familial Diabetes MellitusAPPL proteins FRET at the BAR: direct observation of APPL1 and APPL2 BAR domain-mediated interactions on cell membranes using FRET microscopyInsulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.N-wasp and the arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapsesA possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac diseaseAdiponectin and insulin cross talk: the microvascular connection.Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivityMembrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides.Activation of Rac by Asef2 promotes myosin II-dependent contractility to inhibit cell migration on type I collagenYin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cellsCluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membranePalmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis.Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment.Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblastsT-cell and B-cell signaling biomarkers and treatment targets in lupus.Isoform-specific regulation of Akt signaling by the endosomal protein WDFY2.Insulin resistance for glucose uptake and Akt2 phosphorylation in the soleus, but not epitrochlearis, muscles of old vs. adult ratsCdo interacts with APPL1 and activates Akt in myoblast differentiation.The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial.Appl1 is dispensable for Akt signaling in vivo and mouse T-cell developmentEarly endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomesActivation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradationAssociation of genetic variation in adaptor protein APPL1/APPL2 loci with non-alcoholic fatty liver diseaseThe adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathwayMechanisms for increased insulin-stimulated Akt phosphorylation and glucose uptake in fast- and slow-twitch skeletal muscles of calorie-restricted ratsAPPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathwayAPPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice.Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis.The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration.A novel method to measure glucose uptake and myosin heavy chain isoform expression of single fibers from rat skeletal muscle.Adiponectin action: a combination of endocrine and autocrine/paracrine effects.Deficiency of APPL1 in mice impairs glucose-stimulated insulin secretion through inhibition of pancreatic beta cell mitochondrial function.Rab5 proteins regulate activation and localization of target of rapamycin complex 1.Dual functions of adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) in insulin signaling and insulin secretion.APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in micePhosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates endoplasmic reticulum (ER) stress-induced insulin resistance in hepatocytesThe Rho family GEF Asef2 regulates cell migration in three dimensional (3D) collagen matrices through myosin II
P2860
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P248
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P2860
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
@ast
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
@en
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
@en-gb
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
@nl
type
label
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
@ast
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
@en
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
@en-gb
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
@nl
prefLabel
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
@ast
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
@en
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
@en-gb
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
@nl
P2093
P2860
P921
P3181
P356
P1476
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation
@en
P2093
Christine C Jones
Michael P Czech
Shaohui Huang
Tsugumichi Saito
P2860
P304
32280-32287
P3181
P356
10.1074/JBC.M704150200
P407
P50
P577
2007-09-11T00:00:00Z