APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice.
about
Developmental roles of tribbles protein family membersAdiponectin and insulin cross talk: the microvascular connection.Globular adiponectin enhances muscle insulin action via microvascular recruitment and increased insulin deliveryAdiponectin signaling in the liverAssociation of genetic variation in adaptor protein APPL1/APPL2 loci with non-alcoholic fatty liver diseaseAPPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.APPL1 acts as a protective factor against podocytes injury in high glucose environment.Deficiency of APPL1 in mice impairs glucose-stimulated insulin secretion through inhibition of pancreatic beta cell mitochondrial function.APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in miceEndothelial overexpression of endothelin-1 modulates aortic, carotid, iliac and renal arterial responses in obese mice.The link between metabolic abnormalities and endothelial dysfunction in type 2 diabetes: an update.Direct effects of adipokines on the heart: focus on adiponectin.Examining the role of insulin in the regulation of cardiovascular health.Endothelial dysfunction in (pre)diabetes: characteristics, causative mechanisms and pathogenic role in type 2 diabetes.The role of adiponectin signaling in metabolic syndrome and cancer.Obesity impairs vasodilatation and blood flow increase mediated by endothelial nitric oxide: an overview.The injurious effects of hyperinsulinism on blood vessels.APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes.The impact of insulin resistance on the kidney and vasculature.The cardio-protective signaling and mechanisms of adiponectin.The effect and action mechanism of resveratrol on the vascular endothelial cell by high glucose treatment.TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt.APPL1 transgenic mice are protected from high-fat diet-induced cardiac dysfunction.
P2860
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P2860
APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice.
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
APPL1 counteracts obesity-indu ...... xide and endothelin-1 in mice.
@ast
APPL1 counteracts obesity-indu ...... xide and endothelin-1 in mice.
@en
type
label
APPL1 counteracts obesity-indu ...... xide and endothelin-1 in mice.
@ast
APPL1 counteracts obesity-indu ...... xide and endothelin-1 in mice.
@en
prefLabel
APPL1 counteracts obesity-indu ...... xide and endothelin-1 in mice.
@ast
APPL1 counteracts obesity-indu ...... xide and endothelin-1 in mice.
@en
P2093
P2860
P50
P356
P1433
P1476
APPL1 counteracts obesity-indu ...... xide and endothelin-1 in mice.
@en
P2093
Donghai Wu
Gary Sweeney
Karen S L Lam
Kenneth K Y Cheng
P2860
P304
P356
10.2337/DB11-0666
P407
P577
2011-09-16T00:00:00Z