Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods
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Eukaryotic translation initiation is controlled by cooperativity effects within ternary complexes of 4E-BP1, eIF4E, and the mRNA 5' capStructural Insights into Parasite eIF4E Binding Specificity for m7G and m2,2,7G mRNA CapsStructure-Based Mutational Analysis of eIF4E in Relation to sbm1 Resistance to Pea Seed-Borne Mosaic Virus in PeaCrystal structure of a minimal eIF4E-Cup complex reveals a general mechanism of eIF4E regulation in translational repressionStructural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4EA variant mimicking hyperphosphorylated 4E-BP inhibits protein synthesis in a sea urchin cell-free, cap-dependent translation system.The flexible C-terminal arm of the Lassa arenavirus Z-protein mediates interactions with multiple binding partners.Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E.Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands.Serotonin increases phosphorylation of synaptic 4EBP through TOR, but eukaryotic initiation factor 4E levels do not limit somatic cap-dependent translation in aplysia neurons.Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated GenesMolecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1Distinct recruitment of human eIF4E isoforms to processing bodies and stress granulesSurvey of the year 2005 commercial optical biosensor literature.The oncogene eIF4E: using biochemical insights to target cancer.Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis.Protein intrinsic disorder and oligomericity in cell signaling.Cap-dependent translation initiation factor eIF4E: an emerging anticancer drug target.Potential therapeutic applications of RNA cap analogs.The eukaryotic translation initiation factor eIF4E in the nucleus: taking the road less traveled.Stopped-flow kinetic analysis of eIF4E and phosphorylated eIF4E binding to cap analogs and capped oligoribonucleotides: evidence for a one-step binding mechanism.4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass.The molecular choreography of protein synthesis: translational control, regulation, and pathways.A general method for rapid and cost-efficient large-scale production of 5' capped RNA.Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate.A unique binding mode of the eukaryotic translation initiation factor 4E for guiding the design of novel peptide inhibitors.The SCHOOL of nature: II. Protein order, disorder and oligomericity in transmembrane signaling.Unusual biophysics of immune signaling-related intrinsically disordered proteins.A collection of caged compounds for probing roles of local translation in neurobiology.Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding.The translational repressor 4E-BP called to order by eIF4E: new structural insights by SAXS.Stacking efficiency and flexibility analysis of aromatic amino acids in cap-binding proteins.Structural scaffold for eIF4E binding selectivity of 4E-BP isoforms: crystal structure of eIF4E binding region of 4E-BP2 and its comparison with that of 4E-BP1.Structural basis for LeishIF4E-1 modulation by an interacting protein in the human parasite Leishmania major.
P2860
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P2860
Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Structural basis for mRNA Cap- ...... ar dynamics simulation methods
@ast
Structural basis for mRNA Cap- ...... ar dynamics simulation methods
@en
Structural basis for mRNA Cap- ...... ar dynamics simulation methods
@en-gb
Structural basis for mRNA Cap- ...... ar dynamics simulation methods
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type
label
Structural basis for mRNA Cap- ...... ar dynamics simulation methods
@ast
Structural basis for mRNA Cap- ...... ar dynamics simulation methods
@en
Structural basis for mRNA Cap- ...... ar dynamics simulation methods
@en-gb
Structural basis for mRNA Cap- ...... ar dynamics simulation methods
@nl
prefLabel
Structural basis for mRNA Cap- ...... ar dynamics simulation methods
@ast
Structural basis for mRNA Cap- ...... ar dynamics simulation methods
@en
Structural basis for mRNA Cap- ...... ar dynamics simulation methods
@en-gb
Structural basis for mRNA Cap- ...... ar dynamics simulation methods
@nl
P2093
P921
P3181
P1476
Structural basis for mRNA Cap- ...... ar dynamics simulation methods
@en
P2093
Fumi Abiko
Hiroo Miyagawa
Hiroyuki Fujisaki
Kin-ichiro Miura
Koji Tomoo
Kunihiro Kitamura
Taizo Taniguchi
Toshimasa Ishida
Yasunori Matsushita
P304
P3181
P356
10.1016/J.BBAPAP.2005.07.023
P407
P577
2005-12-01T00:00:00Z