Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis
about
Tunneling nanotubes provide a unique conduit for intercellular transfer of cellular contents in human malignant pleural mesotheliomaThe TORC2 component, Sin1, controls migration of anterior mesendoderm during zebrafish gastrulationRegulation and function of P-Rex family Rac-GEFsMicroRNA signature characterizes primary tumors that metastasize in an esophageal adenocarcinoma rat modelSignaling networks that regulate cell migrationPKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophilsAdhesion molecule periplakin is involved in cellular movement and attachment in pharyngeal squamous cancer cellsAndrogen Receptor-dependent Expression of Low-density Lipoprotein Receptor-related Protein 6 is Necessary for Prostate Cancer Cell Proliferation.Cytoplasmic BRMS1 expression in malignant melanoma is associated with increased disease-free survival.P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.Genomic loss of tumor suppressor miRNA-204 promotes cancer cell migration and invasion by activating AKT/mTOR/Rac1 signaling and actin reorganizationTranslationally controlled tumor protein induces epithelial to mesenchymal transition and promotes cell migration, invasion and metastasisConditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumorsTetraspanin 8-rictor-integrin α3 complex is required for glioma cell migration.SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.Rac signaling in breast cancer: a tale of GEFs and GAPs.TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosisSynergistic induction of cancer cell migration regulated by Gβγ and phosphatidylinositol 3-kinase.Arachidonic acid promotes skin wound healing through induction of human MSC migration by MT3-MMP-mediated fibronectin degradation.PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy.Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALINGAkt3 knockdown induces mitochondrial dysfunction in human cancer cells.mTORC2 mediates CXCL12-induced angiogenesisIntrinsic cellular signaling mechanisms determine the sensitivity of cancer cells to virus-induced apoptosis.Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer.mTORC1- and mTORC2-interacting proteins keep their multifunctional partners focused.Homeostasis and the importance for a balance between AKT/mTOR activity and intracellular signaling.Gβγ Pathways in Cell Polarity and Migration Linked to Oncogenic GPCR Signaling: Potential Relevance in Tumor Microenvironment.Inhibitory role of polyunsaturated fatty acids on lysophosphatidic acid-induced cancer cell migration and adhesion.mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression.AKT/PKB Signaling: Navigating the Network.PtdIns(3,4,5)P3-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling.Cooperation between p21 and Akt is required for p53-dependent cellular senescence.An orthotopic model of metastatic nasopharyngeal carcinoma and its application in elucidating a therapeutic target that inhibits metastasis.The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy.Multisite phosphorylation of P-Rex1 by protein kinase C.MYO6 Regulates Spatial Organization of Signaling Endosomes Driving AKT Activation and Actin Dynamics.NGF signaling in PC12 cells: the cooperation of p75(NTR) with TrkA is needed for the activation of both mTORC2 and the PI3K signalling cascade.
P2860
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P2860
Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Selective activation of Akt1 b ...... tion, invasion, and metastasis
@ast
Selective activation of Akt1 b ...... tion, invasion, and metastasis
@en
Selective activation of Akt1 b ...... tion, invasion, and metastasis
@nl
type
label
Selective activation of Akt1 b ...... tion, invasion, and metastasis
@ast
Selective activation of Akt1 b ...... tion, invasion, and metastasis
@en
Selective activation of Akt1 b ...... tion, invasion, and metastasis
@nl
prefLabel
Selective activation of Akt1 b ...... tion, invasion, and metastasis
@ast
Selective activation of Akt1 b ...... tion, invasion, and metastasis
@en
Selective activation of Akt1 b ...... tion, invasion, and metastasis
@nl
P2093
P3181
P356
P1433
P1476
Selective activation of Akt1 b ...... tion, invasion, and metastasis
@en
P2093
P2888
P304
P3181
P356
10.1038/ONC.2011.22
P407
P577
2011-06-30T00:00:00Z
P6179
1027711106