Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase - Wikidata - awgldk - TriplyDB

Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

http://www.wikidata.org/entity/Q24293757

about

Defining human ERAD networks through an integrative mapping strategy SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology Cleaning up in the endoplasmic reticulum: ubiquitin in charge Live cell imaging of protein dislocation from the endoplasmic reticulum.ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways.Human liver cytochrome P450 3A4 ubiquitination: molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexes The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase Regulation of HMG-CoA reductase in mammals and yeast Clustered hydrophobic amino acids in amphipathic helices mediate erlin1/2 complex assembly.Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum Regulated Erlin-dependent release of the B12 transmembrane J-protein promotes ER membrane penetration of a non-enveloped virus.Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes.Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells.A novel ER-microtubule-binding protein, ERLIN2, stabilizes Cyclin B1 and regulates cell cycle progression.Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4 The mammalian endoplasmic reticulum-associated degradation system Endoplasmic reticulum factor ERLIN2 regulates cytosolic lipid content in cancer cells Interaction between salt-inducible kinase 2 (SIK2) and p97/valosin-containing protein (VCP) regulates endoplasmic reticulum (ER)-associated protein degradation in mammalian cells.Cellular pathways of hereditary spastic paraplegia.Different functions of HOPS isoforms in the cell: HOPS shuttling isoform is determined by RIP cleavage system Lunapark Is a Component of a Ubiquitin Ligase Complex Localized to the Endoplasmic Reticulum Three-way Junctions.Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.Contribution of Extracellular Matrix and Signal Mechanotransduction to Epithelial Cell Damage in Inflammatory Bowel Disease Patients: A Proteomic Study.MicroRNA-7 mediates cross-talk between metabolic signaling pathways in the liver.Microarray analysis reveals Tmub1 as a cell cycle-associated protein in rat hepatocytes.TMUB1 Inhibits BRL-3A Hepatocyte Proliferation by Interfering with the Binding of CAML to Cyclophilin B through its TM1 Hydrophobic Domain.Regulation of INSIG2 by microRNA-96

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P2860

Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

http://www.wikidata.org/entity/Q24293757

description

2011 nî lūn-bûn

@nan

2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Membrane-associated ubiquitin ...... lglutaryl-coenzyme A reductase

@ast

Membrane-associated ubiquitin ...... lglutaryl-coenzyme A reductase

@en

Membrane-associated ubiquitin ...... lglutaryl-coenzyme A reductase

@en-gb

Membrane-associated ubiquitin ...... lglutaryl-coenzyme A reductase

@nl

type

label

Membrane-associated ubiquitin ...... lglutaryl-coenzyme A reductase

@ast

Membrane-associated ubiquitin ...... lglutaryl-coenzyme A reductase

@en

Membrane-associated ubiquitin ...... lglutaryl-coenzyme A reductase

@en-gb

Membrane-associated ubiquitin ...... lglutaryl-coenzyme A reductase

@nl

prefLabel

Membrane-associated ubiquitin ...... lglutaryl-coenzyme A reductase

@ast

Membrane-associated ubiquitin ...... lglutaryl-coenzyme A reductase

@en

Membrane-associated ubiquitin ...... lglutaryl-coenzyme A reductase

@en-gb

Membrane-associated ubiquitin ...... lglutaryl-coenzyme A reductase

@nl

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P356

JBC.M110.211326

P1433

Journal of Biological Chemistry

P1476

Membrane-associated ubiquitin ...... lglutaryl-coenzyme A reductase

@en

P2093

Peter V Sguigna

http://www.w3.org/2001/XMLSchema#string

Russell A DeBose-Boyd

http://www.w3.org/2001/XMLSchema#string

Youngah Jo

http://www.w3.org/2001/XMLSchema#string

P2860

Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER

The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step

One step at a time: endoplasmic reticulum-associated degradation

RING domain E3 ubiquitin ligases

A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation.

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins.

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15022-31

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scholarly article

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10.1074/JBC.M110.211326

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P407

P433

17

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P478

286

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2011-04-29T00:00:00Z

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49856908

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21343306

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P921

ubiquitin-dependent ERAD pathway

Transmembrane and ubiquitin like domain containing 1

P932

3083207

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