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The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIαRab18 and a Rab18 GEF complex are required for normal ER structure.MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesisIdentification and functional analysis of a SLC33A1: c.339T>G (p.Ser113Arg) variant in the original SPG42 familyHereditary spastic paraplegia type 43 (SPG43) is caused by mutation in C19orf12Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formationMutation in CPT1C Associated With Pure Autosomal Dominant Spastic ParaplegiaPhosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamicsLoss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humansIs Modulation of Oxidative Stress an Answer? The State of the Art of Redox Therapeutic Actions in Neurodegenerative DiseasesThe Crossroads of Synaptic Growth Signaling, Membrane Traffic and Neurological Disease: Insights from DrosophilaNeuronal endoplasmic reticulum stress in axon injury and neurodegenerationMembrane-shaping disorders: a common pathway in axon degenerationAdaptor protein complexes AP-4 and AP-5: new players in endosomal trafficking and progressive spastic paraplegiaOxidative Stress in Caenorhabditis elegans: Protective Effects of SpartinCYP2U1 mutations in two Iranian patients with activity induced dystonia, motor regression and spastic paraplegia.A hereditary spastic paraplegia mouse model supports a role of ZFYVE26/SPASTIZIN for the endolysosomal systemHereditary spastic paraplegia SPG4: what is known and not known about the disease.Misregulation of a DDHD Domain-containing Lipase Causes Mitochondrial Dysfunction in YeastDelving into the complexity of hereditary spastic paraplegias: how unexpected phenotypes and inheritance modes are revolutionizing their nosologyExome sequencing links corticospinal motor neuron disease to common neurodegenerative disordersProtrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegiaSpg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signalingPMCA4 (ATP2B4) mutation in familial spastic paraplegia.Clinical and Paraclinical Indicators of Motor System Impairment in Hereditary Spastic Paraplegia: A Pilot StudyA spastic paraplegia mouse model reveals REEP1-dependent ER shaping.Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation.Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration.Contacts between the endoplasmic reticulum and other membranes in neurons.Souffle/Spastizin controls secretory vesicle maturation during zebrafish oogenesis.How implementation of systems biology into clinical trials accelerates understanding of diseases.Lysosomal abnormalities in hereditary spastic paraplegia types SPG15 and SPG11.Motor protein mutations cause a new form of hereditary spastic paraplegiaLoss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease.Pharmacologic rescue of axon growth defects in a human iPSC model of hereditary spastic paraplegia SPG3A.Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and axon development.A novel homozygous p.R1105X mutation of the AP4E1 gene in twins with hereditary spastic paraplegia and mycobacterial disease.Mitochondrial fission augments capsaicin-induced axonal degenerationLunapark stabilizes nascent three-way junctions in the endoplasmic reticulumA conserved amphipathic helix is required for membrane tubule formation by Yop1p
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Cellular pathways of hereditary spastic paraplegia.
@en
type
label
Cellular pathways of hereditary spastic paraplegia.
@en
prefLabel
Cellular pathways of hereditary spastic paraplegia.
@en
P2860
P1476
Cellular pathways of hereditary spastic paraplegia.
@en
P2093
Craig Blackstone
P2860
P356
10.1146/ANNUREV-NEURO-062111-150400
P577
2012-04-20T00:00:00Z