The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization - Wikidata - awgldk - TriplyDB

The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization

The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization

http://www.wikidata.org/entity/Q24293767

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GPR50 is the mammalian ortholog of Mel1c: evidence of rapid evolution in mammals International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors.Heteromerization of G protein-coupled receptors: relevance to neurological disorders and neurotherapeutics.Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers A Review of Melatonin, Its Receptors and Drugs Melatoninergic System in Parkinson's Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Melatonin receptor expression in Xenopus laevis surface corneal epithelium: diurnal rhythm of lateral membrane localization.Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population.Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Whole exome sequencing identifies a novel EMD mutation in a Chinese family with dilated cardiomyopathy GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling.The Epstein-Barr virus-encoded G protein-coupled receptor BILF1 hetero-oligomerizes with human CXCR4, scavenges Gαi proteins, and constitutively impairs CXCR4 functioning.Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus.Action of molecular switches in GPCRs--theoretical and experimental studies.Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.Application of G protein-coupled receptor-heteromer identification technology to monitor β-arrestin recruitment to G protein-coupled receptor heteromers Purification and identification of G protein-coupled receptor protein complexes under native conditions.GPCR Heterodimerization in the Reproductive System: Functional Regulation and Implication for Biodiversity Distribution of MT1 melatonin receptor promoter-driven RFP expression in the brains of BAC C3H/HeN transgenic mice.Heteromerization of human cytomegalovirus encoded chemokine receptors.Involvement of GPR50 polymorphisms in depression: independent replication in a prospective elderly cohort.Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors.Melatonin: an inhibitor of breast cancer.Constitutive Activity among Orphan Class-A G Protein Coupled Receptors Melatonin membrane receptors in peripheral tissues: distribution and functions Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand.Identification and profiling of novel α1A-adrenoceptor-CXC chemokine receptor 2 heteromer.The pattern of melatonin receptor expression in the brain may influence antidepressant treatment Melatonin in aging and disease -multiple consequences of reduced secretion, options and limits of treatment.Developmental expression of orphan G protein-coupled receptor 50 in the mouse brain.Resveratrol: brain effects on SIRT1, GPR50 and photoperiodic signaling.Molecules affecting hypothalamic control of core body temperature in response to calorie intake.

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P2860

The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization

http://www.wikidata.org/entity/Q24293767

description

2006 nî lūn-bûn

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2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2006 թվականի հուլիսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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The orphan GPR50 receptor spec ...... ion through heterodimerization

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The orphan GPR50 receptor spec ...... ion through heterodimerization

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The orphan GPR50 receptor spec ...... ion through heterodimerization

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The orphan GPR50 receptor spec ...... ion through heterodimerization

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The orphan GPR50 receptor spec ...... ion through heterodimerization

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The orphan GPR50 receptor spec ...... ion through heterodimerization

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The orphan GPR50 receptor spec ...... ion through heterodimerization

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The orphan GPR50 receptor spec ...... ion through heterodimerization

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SJ.EMBOJ.7601193

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The EMBO Journal

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The orphan GPR50 receptor spec ...... ion through heterodimerization

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Cyril Couturier

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Jean-Luc Guillaume

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Philippe Delagrange

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Ralf Jockers

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P2860

Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation

Human MicroRNA targets

Heterodimerization is required for the formation of a functional GABA(B) receptor

Cloning of a melatonin-related receptor from human pituitary

Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands.

Different functional roles of T1R subunits in the heteromeric taste receptors

The G protein-coupled receptor repertoires of human and mouse

Cross genome phylogenetic analysis of human and Drosophila G protein-coupled receptors: application to functional annotation of orphan receptors.

Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins

Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer

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3012-3023

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10.1038/SJ.EMBOJ.7601193

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13

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25

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Angélique Levoye

Mohammed A Ayoub

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2006-06-15T00:00:00Z

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7004548

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16778767

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identical protein binding

G protein-coupled receptor 50

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1500982

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