Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2 - Wikidata - awgldk - TriplyDB

Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2

Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2

http://www.wikidata.org/entity/Q24297056

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The dynamic cilium in human diseases Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1 Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha A polycystin-centric view of cyst formation and disease: the polycystins revisited Regulation of STATs by polycystin-1 and their role in polycystic kidney disease Experimental therapies and ongoing clinical trials to slow down progression of ADPKD The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies The axoneme: the propulsive engine of spermatozoa and cilia and associated ciliopathies leading to infertility Nedd9 restrains renal cystogenesis in Pkd1-/- mice Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease When cilia go bad: cilia defects and ciliopathies E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion.A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7 A mitotic transcriptional switch in polycystic kidney disease Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex.Virtual-tissue computer simulations define the roles of cell adhesion and proliferation in the onset of kidney cystic disease Domain mapping of the polycystin-2 C-terminal tail using de novo molecular modeling and biophysical analysis.Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2.Inhibitor of differentiation 4 (Id4) is a potential tumor suppressor in prostate cancer.A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus.Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 (polycystin-2)-dependent manner.Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways Polycystic kidney disease.Novel targets for the treatment of autosomal dominant polycystic kidney disease.Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain.Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease Molecular diagnostics for autosomal dominant polycystic kidney disease The cell biology of polycystic kidney disease The retinitis pigmentosa protein RP2 interacts with polycystin 2 and regulates cilia-mediated vertebrate development.Rapid calcium-dependent activation of Aurora-A kinase.Protein kinase D-mediated phosphorylation of polycystin-2 (TRPP2) is essential for its effects on cell growth and calcium channel activity.Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation.Kidney: polycystic kidney disease.Epigenetic inactivation of inhibitor of differentiation 4 (Id4) correlates with prostate cancer The versatile nature of the calcium-permeable cation channel TRPP2 At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis.Aurora A kinase activity influences calcium signaling in kidney cells.

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P2860

Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2

http://www.wikidata.org/entity/Q24297056

description

2005 nî lūn-bûn

@nan

2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Polycystin-1 and polycystin-2 ...... helix-loop-helix inhibitor Id2

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Polycystin-1 and polycystin-2 ...... helix-loop-helix inhibitor Id2

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Polycystin-1 and polycystin-2 ...... helix-loop-helix inhibitor Id2

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Polycystin-1 and polycystin-2 ...... helix-loop-helix inhibitor Id2

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Polycystin-1 and polycystin-2 ...... helix-loop-helix inhibitor Id2

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Polycystin-1 and polycystin-2 ...... helix-loop-helix inhibitor Id2

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Polycystin-1 and polycystin-2 ...... helix-loop-helix inhibitor Id2

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Polycystin-1 and polycystin-2 ...... helix-loop-helix inhibitor Id2

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Polycystin-1 and polycystin-2 ...... helix-loop-helix inhibitor Id2

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Polycystin-1 and polycystin-2 ...... helix-loop-helix inhibitor Id2

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Polycystin-1 and polycystin-2 ...... helix-loop-helix inhibitor Id2

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Polycystin-1 and polycystin-2 ...... helix-loop-helix inhibitor Id2

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Nature Cell Biology

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Polycystin-1 and polycystin-2 ...... helix-loop-helix inhibitor Id2

@en

P2093

Coleen A McNamara

http://www.w3.org/2001/XMLSchema#string

Jing Zhou

http://www.w3.org/2001/XMLSchema#string

Patrick G Starremans

http://www.w3.org/2001/XMLSchema#string

Xiaogang Li

http://www.w3.org/2001/XMLSchema#string

Ying Luo

http://www.w3.org/2001/XMLSchema#string

York Pei

http://www.w3.org/2001/XMLSchema#string

P2860

Polycystin-2 is an intracellular calcium release channel

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

Identification of c-MYC as a target of the APC pathway

Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2

Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation

PKD1 interacts with PKD2 through a probable coiled-coil domain

The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

Polycystin-2 interacts with troponin I, an angiogenesis inhibitor

Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors

A novel genetic system to detect protein-protein interactions

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1202-12

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scholarly article

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3198529

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10.1038/NCB1326

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12

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7

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7456579

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1028780953

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16311606

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P921

negative regulation of G1/S transition of mitotic cell cycle

Polycystin 1, transient receptor poteintial channel interacting

Polycystin 1, transient receptor potential channel interacting

Polycystin 2, transient receptor potential cation channel

Inhibitor of DNA binding 2

Inhibitor of DNA binding 2