Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells
about
Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal lossRegulation of intracellular signaling by extracellular glycan remodeling.Transcriptome profiling of bovine milk oligosaccharide metabolism genes using RNA-sequencing.LPS-induced cytokine production in human dendritic cells is regulated by sialidase activityStructural basis for substrate specificity of mammalian neuraminidases.Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for Toll-like receptor activation and cellular signaling.Role of Sialidase in Long-Term Potentiation at Mossy Fiber-CA3 Synapses and Hippocampus-Dependent Spatial Memory.Neuraminidase-1 contributes significantly to the degradation of neuronal B-series gangliosides but not to the bypass of the catabolic block in Tay-Sachs mouse models.Cell-permeable probe for identification and imaging of sialidasesCell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity.Aberrant expression of sialidase and cancer progression.Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiationHeterodimerization of the sialidase NEU1 with the chaperone protective protein/cathepsin A prevents its premature oligomerization.Sialidase significance for cancer progression.Glycoengineering of CHO Cells to Improve Product Quality.Regulation of sialyl Lewis antigen expression in colon cancer cells by sialidase NEU4.Role of Neu4L sialidase and its substrate ganglioside GD3 in neuronal apoptosis induced by catechol metabolites.Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments.Evidence for mitochondrial localization of a novel human sialidase (NEU4).Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio).Identifying selective inhibitors against the human cytosolic sialidase NEU2 by substrate specificity studies.Human sialidase NEU4 long and short are extrinsic proteins bound to outer mitochondrial membrane and the endoplasmic reticulum, respectively.Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model.Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage.Myelin extracellular leaflet compaction requires apolipoprotein D membrane management to optimize lysosomal-dependent recycling and glycocalyx removal.Rapid regulation of sialidase activity in response to neural activity and sialic acid removal during memory processing in rat hippocampus.Dependence of neurotrophic factor activation of Trk tyrosine kinase receptors on cellular sialidase.Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen)NEU1;4 hydrolyses Neu5Ac from glycoconjugatesAntibody-mediated sialidase activity in blood serum of patients with multiple myeloma.Molecular cloning and biochemical characterization of medaka (Oryzias latipes) lysosomal neu4 sialidase.Keeping it trim: roles of neuraminidases in CNS function
P2860
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P2860
Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells
description
2004 nî lūn-bûn
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2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Neu4, a novel human lysosomal ...... is and galactosialidosis cells
@ast
Neu4, a novel human lysosomal ...... is and galactosialidosis cells
@en
Neu4, a novel human lysosomal ...... is and galactosialidosis cells
@en-gb
Neu4, a novel human lysosomal ...... is and galactosialidosis cells
@nl
type
label
Neu4, a novel human lysosomal ...... is and galactosialidosis cells
@ast
Neu4, a novel human lysosomal ...... is and galactosialidosis cells
@en
Neu4, a novel human lysosomal ...... is and galactosialidosis cells
@en-gb
Neu4, a novel human lysosomal ...... is and galactosialidosis cells
@nl
prefLabel
Neu4, a novel human lysosomal ...... is and galactosialidosis cells
@ast
Neu4, a novel human lysosomal ...... is and galactosialidosis cells
@en
Neu4, a novel human lysosomal ...... is and galactosialidosis cells
@en-gb
Neu4, a novel human lysosomal ...... is and galactosialidosis cells
@nl
P2093
P921
P3181
P356
P1476
Neu4, a novel human lysosomal ...... is and galactosialidosis cells
@en
P2093
Alexey V Pshezhetsky
Carlos R Morales
Jacob A Hassan
Karine Landry
Stéphanie Trudel
Volkan Seyrantepe
P304
P3181
P356
10.1074/JBC.M404531200
P407
P577
2004-08-27T00:00:00Z