Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity
about
Arl2- and Msps-dependent microtubule growth governs asymmetric divisionBiallelic Mutations in TBCD, Encoding the Tubulin Folding Cofactor D, Perturb Microtubule Dynamics and Cause Early-Onset EncephalopathyThe ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels.The Hsp70 and Hsp40 chaperones influence microtubule stability in ChlamydomonasTubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamicsResponses of Bovine Innate Immunity to Mycobacterium avium subsp. paratuberculosis Infection Revealed by Changes in Gene Expression and Levels of MicroRNA.The abundance of the ARL2 GTPase and its GAP, ELMOD2, at mitochondria are modulated by the fusogenic activity of mitofusins and stressors.Higher order signaling: ARL2 as regulator of both mitochondrial fusion and microtubule dynamics allows integration of 2 essential cell functions.Revisiting the tubulin cofactors and Arl2 in the regulation of soluble αβ-tubulin pools and their effect on microtubule dynamics.The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function.Tubulin-specific chaperones: components of a molecular machine that assembles the α/β heterodimer.Common variants on 17q25 and gene-gene interactions conferring risk of schizophrenia in Han Chinese population and regulating gene expressions in human brain.The dual role of fission yeast Tbc1/cofactor C orchestrates microtubule homeostasis in tubulin folding and acts as a GAP for GTPase Alp41/Arl2.Microcephaly, intractable seizures and developmental delay caused by biallelic variants in TBCD: further delineation of a new chaperone-mediated tubulinopathy.A Trimer Consisting of the Tubulin-specific Chaperone D (TBCD), Regulatory GTPase ARL2, and β-Tubulin Is Required for Maintaining the Microtubule Network.Nucleotide Binding to ARL2 in the TBCD∙ARL2∙β-Tubulin Complex Drives Conformational Changes in β-Tubulin.The ARL2 GTPase regulates mitochondrial fusion from the intermembrane space.TBCD may be a causal gene in progressive neurodegenerative encephalopathy with atypical infantile spinal muscular atrophy.Tracking Effects of SIL1 Increase: Taking a Closer Look Beyond the Consequences of Elevated Expression Level.Beta-tubulin:GTP + Cofactor D -> Beta-tubulin:GTP: Cofactor DARL2BP, a protein linked to Retinitis Pigmentosa, is needed for normal photoreceptor cilia doublets and outer segment structure.Severe presentation of WDR62 mutation: is there a role for modifying genetic factors?
P2860
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P2860
Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity
description
2010 nî lūn-bûn
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2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
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name
Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity
@ast
Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity
@en
Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity
@en-gb
Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity
@nl
type
label
Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity
@ast
Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity
@en
Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity
@en-gb
Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity
@nl
prefLabel
Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity
@ast
Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity
@en
Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity
@en-gb
Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity
@en
P2093
Guoling Tian
Nicholas J Cowan
Simi Thomas
P2860
P304
P3181
P356
10.1002/CM.20480
P407
P577
2010-11-01T00:00:00Z