Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death
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Dominant negative mutations affect oligomerization of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidyHuman pyruvate kinase M2: a multifunctional proteinAnticancer strategies based on the metabolic profile of tumor cells: therapeutic targeting of the Warburg effectPyruvate Kinase M2: A Potential Target for Regulating InflammationDysregulated metabolism contributes to oncogenesisStructure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewNanonets Collect Cancer Secretome from Pericellular SpaceAllosteric Mechanism of Pyruvate Kinase from Leishmania mexicana Uses a Rock and Lock ModelPyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesisM2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.Metabolic reprogramming: a cancer hallmark even warburg did not anticipateMultiplex N-terminome analysis of MMP-2 and MMP-9 substrate degradomes by iTRAQ-TAILS quantitative proteomicsMass spectrometric characterization of protein structure details refines the proteome signature for invasive ductal breast carcinoma.A proteomic study of cMyc improvement of CHO culture.Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice.Biosignatures for Parkinson's disease and atypical parkinsonian disorders patients.Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer questionExploiting unique structural and functional properties of malarial glycolytic enzymes for antimalarial drug developmentGenome-scale identification and characterization of moonlighting proteins.Proteomic-based approach to gain insight into reprogramming of THP-1 cells exposed to Leishmania donovani over an early temporal window.Isoform switch of pyruvate kinase M1 indeed occurs but not to pyruvate kinase M2 in human tumorigenesis.PKM2 Subcellular Localization Is Involved in Oxaliplatin Resistance Acquisition in HT29 Human Colorectal Cancer Cell Lines.Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma.Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.Phage display library selection of a hypoxia-binding scFv antibody for liver cancer metabolic marker discovery.ERK2-Pyruvate Kinase Axis Permits Phorbol 12-Myristate 13-Acetate-induced Megakaryocyte Differentiation in K562 CellsThe protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging.Proteomic profiling of ATM kinase proficient and deficient cell lines upon blockage of proteasome activity.PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesisNuclear PKM2 contributes to gefitinib resistance via upregulation of STAT3 activation in colorectal cancer.Emerging roles of PKM2 in cell metabolism and cancer progressionPKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activationAnticancer agents that counteract tumor glycolysis.SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1Discovery and verification of head-and-neck cancer biomarkers by differential protein expression analysis using iTRAQ labeling, multidimensional liquid chromatography, and tandem mass spectrometryChronic exposure to chewing tobacco selects for overexpression of stearoyl-CoA desaturase in normal oral keratinocytes.Cytokine-induced nuclear translocation of signaling proteins and their analysis using the inducible translocation trap system.Proteomic analysis of protein expression profiles during hyperthermia-induced apoptosis in Tca8113 cellsCancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator.
P2860
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P2860
Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Nuclear translocation of the t ...... induces programmed cell death
@ast
Nuclear translocation of the t ...... induces programmed cell death
@en
Nuclear translocation of the t ...... induces programmed cell death
@en-gb
Nuclear translocation of the t ...... induces programmed cell death
@nl
type
label
Nuclear translocation of the t ...... induces programmed cell death
@ast
Nuclear translocation of the t ...... induces programmed cell death
@en
Nuclear translocation of the t ...... induces programmed cell death
@en-gb
Nuclear translocation of the t ...... induces programmed cell death
@nl
prefLabel
Nuclear translocation of the t ...... induces programmed cell death
@ast
Nuclear translocation of the t ...... induces programmed cell death
@en
Nuclear translocation of the t ...... induces programmed cell death
@en-gb
Nuclear translocation of the t ...... induces programmed cell death
@nl
P2093
P3181
P1433
P1476
Nuclear translocation of the t ...... induces programmed cell death
@en
P2093
Attila Steták
Axel Ullrich
György Kéri
Judit Ovádi
Péter Csermely
Réka Veress
P304
P3181
P356
10.1158/0008-5472.CAN-06-2870
P407
P577
2007-02-15T00:00:00Z