Dominant negative mutations affect oligomerization of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy

Dominant negative mutations affect oligomerization of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy

Item
http://www.wikidata.org/entity/Q24604119
Human pyruvate kinase M2: a multifunctional proteinPyruvate kinase M2 at a glanceResveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin.Missense mutations in pyruvate kinase M2 promote cancer metabolism, oxidative endurance, anchorage independence, and tumor growth in a dominant negative manner.In silico screening, genotyping, molecular dynamics simulation and activity studies of SNPs in pyruvate kinase M2Structural insight into mechanisms for dynamic regulation of PKM2.ERK2-Pyruvate Kinase Axis Permits Phorbol 12-Myristate 13-Acetate-induced Megakaryocyte Differentiation in K562 CellsInsulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2.Pyruvate kinase M knockdown-induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival.Moderate DNA damage promotes metabolic flux into PPP via PKM2 Y-105 phosphorylation: a feature that favours cancer cells.Molecular simulation of Tyr105 phosphorylated pyruvate kinase M2 to understand its structure and dynamics.
P2860

Dominant negative mutations affect oligomerization of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy

Item
http://www.wikidata.org/entity/Q24604119
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2010 nî lūn-bûn
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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2010 թվականի մայիսին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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name
Dominant negative mutations af ...... cellular growth and polyploidy
@ast
Dominant negative mutations af ...... cellular growth and polyploidy
@en
Dominant negative mutations af ...... cellular growth and polyploidy
@nl
type
label
Dominant negative mutations af ...... cellular growth and polyploidy
@ast
Dominant negative mutations af ...... cellular growth and polyploidy
@en
Dominant negative mutations af ...... cellular growth and polyploidy
@nl
prefLabel
Dominant negative mutations af ...... cellular growth and polyploidy
@ast
Dominant negative mutations af ...... cellular growth and polyploidy
@en
Dominant negative mutations af ...... cellular growth and polyploidy
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932
P356
P1433
P1476
Dominant negative mutations af ...... cellular growth and polyploidy
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P921
P932