Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4 - Wikidata - awgldk - TriplyDB

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

http://www.wikidata.org/entity/Q24297637

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Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1 Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling Single small-interfering RNA expression vector for silencing multiple transforming growth factor-beta pathway components Heme oxygenase-1 as a target for TGF-β in kidney disease Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis Phenocopy--a strategy to qualify chemical compounds during hit-to-lead and/or lead optimization Gatifloxacin induces S and G2-phase cell cycle arrest in pancreatic cancer cells via p21/p27/p53 Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo.Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses.The effect of transforming growth factor-beta1 on nasopharyngeal carcinoma cells: insensitive to cell growth but functional to TGF-beta/Smad pathway Requirement of a dynein light chain in TGFbeta/Smad3 signaling.Adeno-associated virus type 2 increases proteosome-dependent degradation of p21WAF1 in a human papillomavirus type 31b-positive cervical carcinoma line Limb-bud and Heart (LBH) functions as a tumor suppressor of nasopharyngeal carcinoma by inducing G1/S cell cycle arrest.A novel approach for the generation of genetically modified mammary epithelial cell cultures yields new insights into TGFβ signaling in the mammary gland Smad proteins differentially regulate transforming growth factor-β-mediated induction of chondroitin sulfate proteoglycans Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor β (TGF-β) pathway.Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-β Smad3 as a mediator of the fibrotic response.TGF-beta signaling in chondrocytes.Kaempferol Suppresses Transforming Growth Factor-β1-Induced Epithelial-to-Mesenchymal Transition and Migration of A549 Lung Cancer Cells by Inhibiting Akt1-Mediated Phosphorylation of Smad3 at Threonine-179.Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts.Biological responses to TGF-β in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression.Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase.Transformation by oncogenic Ras expands the early genomic response to transforming growth factor beta in intestinal epithelial cells.Cell survival and metastasis regulation by Akt signaling in colorectal cancer Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling.Noncanonical TGF-β signaling during mammary tumorigenesis.Cathepsin S-mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction.Differential regulation of transforming growth factor beta signaling pathways by Notch in human endothelial cells SMAD3 and SMAD4 have a more dominant role than SMAD2 in TGFβ-induced chondrogenic differentiation of bone marrow-derived mesenchymal stem cells.Alterations in the Smad pathway in human cancers Specificity protein 1 and Smad-dependent regulation of human heme oxygenase-1 gene by transforming growth factor-beta1 in renal epithelial cells.Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1.Hypoxia-activated Smad3-specific dephosphorylation by PP2A.MiR-1 suppresses tumor cell proliferation in colorectal cancer by inhibition of Smad3-mediated tumor glycolysis.Id proteins: novel targets of activin action, which regulate epidermal homeostasis.The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells.

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Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

http://www.wikidata.org/entity/Q24297637

description

2003 nî lūn-bûn

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2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

@ast

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

@en

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

@nl

type

label

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

@ast

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

@en

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

@nl

prefLabel

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

@ast

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

@en

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

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Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

@en

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Anke Klippel

http://www.w3.org/2001/XMLSchema#string

Anny Kretschmer

http://www.w3.org/2001/XMLSchema#string

Joerg Kaufmann

http://www.w3.org/2001/XMLSchema#string

Kristin Moepert

http://www.w3.org/2001/XMLSchema#string

Maria Sternberger

http://www.w3.org/2001/XMLSchema#string

Sibylle Dames

http://www.w3.org/2001/XMLSchema#string

P2860

The Hallmarks of Cancer

The Smad pathway

Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control

Stoichiometry of active smad-transcription factor complexes on DNA

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

Signal transduction by the TGF-beta superfamily

Repression of p15INK4b expression by Myc through association with Miz-1

Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

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6748-63

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scholarly article

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10.1038/SJ.ONC.1206791

http://www.w3.org/2001/XMLSchema#string

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P433

43

http://www.w3.org/2001/XMLSchema#string

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22

http://www.w3.org/2001/XMLSchema#string

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2003-10-02T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

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5466950

http://www.w3.org/2001/XMLSchema#string

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1028509858

http://www.w3.org/2001/XMLSchema#string

P698

14555988

http://www.w3.org/2001/XMLSchema#string

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positive regulation of transcription, DNA-templated

Transforming growth factor beta 1

SMAD family member 2

SMAD family member 3