Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling
about
Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stressPhosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signalingUbiquitin-proteasome system as a modulator of cell fateParkin Regulation and Neurodegenerative DisordersPathologic and therapeutic implications for the cell biology of parkinMitochondrial dysfunction and oxidative stress in Parkinson's diseaseStructure of the human Parkin ligase domain in an autoinhibited statePINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's diseaseParkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinaseParkin is protective against proteotoxic stress in a transgenic zebrafish modelParkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathyParkin occurs in a stable, non-covalent, approximately 110-kDa complex in brainLoss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent MitophagyIKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.Accumulation of phosphorylated I kappaB alpha and activated IKK in nodes of Ranvier.Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease.Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.Parkin-mediated ubiquitin signalling in aggresome formation and autophagy.Parkin mediates apparent E2-independent monoubiquitination in vitro and contains an intrinsic activity that catalyzes polyubiquitination.Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B.Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin.Identification and characterization of a novel endogenous murine parkin mutation.Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.Does Huntingtin play a role in selective macroautophagy?USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkinProgrammed cell death and new discoveries in the genetics of parkinsonism.Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitinationTumor necrosis factor receptor-associated factor 2 mediates mitochondrial autophagy.Ubiquitination in postsynaptic function and plasticityNigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration.Glutathione s-transferase omega 1 activity is sufficient to suppress neurodegeneration in a Drosophila model of Parkinson diseaseParkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degenerationNeuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic interventionRoles of NF-kappaB in central nervous system damage and repair.The parkin protein as a therapeutic target in Parkinson's disease.Parkin deficiency increases vulnerability to inflammation-related nigral degenerationThe two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases.
P2860
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P2860
Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Parkin mediates neuroprotectio ...... uclear factor-kappaB signaling
@ast
Parkin mediates neuroprotectio ...... uclear factor-kappaB signaling
@en
Parkin mediates neuroprotectio ...... uclear factor-kappaB signaling
@en-gb
Parkin mediates neuroprotectio ...... uclear factor-kappaB signaling
@nl
type
label
Parkin mediates neuroprotectio ...... uclear factor-kappaB signaling
@ast
Parkin mediates neuroprotectio ...... uclear factor-kappaB signaling
@en
Parkin mediates neuroprotectio ...... uclear factor-kappaB signaling
@en-gb
Parkin mediates neuroprotectio ...... uclear factor-kappaB signaling
@nl
altLabel
Parkin Mediates Neuroprotectio ...... se/Nuclear Factor- B Signaling
@en
prefLabel
Parkin mediates neuroprotectio ...... uclear factor-kappaB signaling
@ast
Parkin mediates neuroprotectio ...... uclear factor-kappaB signaling
@en
Parkin mediates neuroprotectio ...... uclear factor-kappaB signaling
@en-gb
Parkin mediates neuroprotectio ...... uclear factor-kappaB signaling
@nl
P2093
P50
P3181
P1476
Parkin mediates neuroprotectio ...... uclear factor-kappaB signaling
@en
P2093
Anita Schlierf
Benedikt Berninger
Elmar Wegener
Iris H Henn
Julia E Schramm
Julia S Schlehe
Kazuhiro Nakaso
Lena Bouman
P304
P3181
P356
10.1523/JNEUROSCI.5537-06.2007
P407
P577
2007-02-01T00:00:00Z