Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint
about
TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks.A dominant negative mutant of TLK1 causes chromosome missegregation and aneuploidy in normal breast epithelial cellsTranslation of the radioresistance kinase TLK1B is induced by gamma-irradiation through activation of mTOR and phosphorylation of 4E-BP1Asf1 facilitates dephosphorylation of Rad53 after DNA double-strand break repair.Checkpoint kinase 1 in DNA damage response and cell cycle regulationRoles of Chk1 in cell biology and cancer therapyThe Drosophila splicing factor PSI is phosphorylated by casein kinase II and tousled-like kinaseATM Signaling PathwayPromising Gene Therapeutics for Salivary Gland RadiotoxicityATR checkpoint kinase and CRL1βTRCP collaborate to degrade ASF1a and thus repress genes overlapping with clusters of stalled replication forks.Regulation of histone deposition proteins Asf1/Hir1 by multiple DNA damage checkpoint kinases in Saccharomyces cerevisiae.Mitotic crisis: the unmasking of a novel role for RPADNA damage response and repair data with pharmacological modulators of Tousled.Tousled kinase TLK1B counteracts the effect of Asf1 in inhibition of histone H3-H4 tetramer formation.TLK1B promotes repair of DSBs via its interaction with Rad9 and Asf1.Chk1 haploinsufficiency results in anemia and defective erythropoiesis.Tousled kinase TLK1B mediates chromatin assembly in conjunction with Asf1 regardless of its kinase activity.Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response.Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo.Replication licensing and the DNA damage checkpoint.Phenothiazine Inhibitors of TLKs Affect Double-Strand Break Repair and DNA Damage Response Recovery and Potentiate Tumor Killing with Radiomimetic Therapy.Checkpoint functions are required for normal S-phase progression in Saccharomyces cerevisiae RCAF- and CAF-I-defective mutantsZygotic G2/M cell cycle arrest induced by ATM/Chk1 activation and DNA repair in mouse embryos fertilized with hydrogen peroxide-treated epididymal mouse sperm.Tousled-like kinase-dependent phosphorylation of Rad9 plays a role in cell cycle progression and G2/M checkpoint exit.Mi-2/NuRD complex function is required for normal S phase progression and assembly of pericentric heterochromatin.The protein kinase TOUSLED is required for maintenance of transcriptional gene silencing in Arabidopsis.Checkpoint kinase1 (CHK1) is an important biomarker in breast cancer having a role in chemotherapy responseAnalysis of the ways and methods of signaling pathways in regulating cell cycle of NIH3T3 at transcriptional levelChk1 Activation Protects Rad9A from Degradation as Part of a Positive Feedback Loop during Checkpoint Signalling.Checking on DNA damage in S phase.Tousled kinase activator, gallic acid, promotes homologous recombinational repair and suppresses radiation cytotoxicity in salivary gland cellsTLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint.Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisionsChromatin disassembly and reassembly during DNA repair.Recombinant AAV9-TLK1B administration ameliorates fractionated radiation-induced xerostomiaThe C. elegans Tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase.Computational framework for analysis of prey-prey associations in interaction proteomics identifies novel human protein-protein interactions and networksReplicating damaged DNA in eukaryotes.Replicating chromatin: a tale of histones.
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P2860
Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint
description
2003 nî lūn-bûn
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2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2003 թվականի ապրիլին հրատարակված գիտական հոդված
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2003年の論文
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2003年論文
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2003年論文
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2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
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2003年论文
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name
Human Tousled like kinases are ...... ependent DNA damage checkpoint
@ast
Human Tousled like kinases are ...... ependent DNA damage checkpoint
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Human Tousled like kinases are ...... ependent DNA damage checkpoint
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Human Tousled like kinases are ...... ependent DNA damage checkpoint
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type
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Human Tousled like kinases are ...... ependent DNA damage checkpoint
@ast
Human Tousled like kinases are ...... ependent DNA damage checkpoint
@en
Human Tousled like kinases are ...... ependent DNA damage checkpoint
@en-gb
Human Tousled like kinases are ...... ependent DNA damage checkpoint
@nl
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Human Tousled like kinases are ...... ependent DNA damage checkpoint
@ast
Human Tousled like kinases are ...... ependent DNA damage checkpoint
@en
Human Tousled like kinases are ...... ependent DNA damage checkpoint
@en-gb
Human Tousled like kinases are ...... ependent DNA damage checkpoint
@nl
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Human Tousled like kinases are ...... ependent DNA damage checkpoint
@en
P2093
Christer Wernstedt
Herman H W Silljé
P2860
P304
P3181
P356
10.1093/EMBOJ/CDG151
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P577
2003-04-01T00:00:00Z