Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver
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Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues.Induction of unique structural changes in guanine-rich DNA regions by the triazoloacridone C-1305, a topoisomerase II inhibitor with antitumor activities.Structural Perturbations Induced by the α-Anomer of the Aflatoxin B 1 Formamidopyrimidine Adduct in Duplex and Single-Strand DNABypass of Aflatoxin B 1 Adducts by the Sulfolobus solfataricus DNA Polymerase IVRole of the modulation of CYP1A1 expression and activity in chemopreventionEvidence of impaired cisapride metabolism in neonatesContributions of human enzymes in carcinogen metabolismCloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase.Kinetics of hydrolysis and reaction of aflatoxin B1 exo-8,9-epoxide and relevance to toxicity and detoxication.Inhibition of Carcinogen-Activating Cytochrome P450 Enzymes by Xenobiotic Chemicals in Relation to Antimutagenicity and Anticarcinogenicity.Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1History of drug metabolism research in Japan.Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liverPotential of an in vitro toolbox combined with exposure data as a first step for the risk assessment of dietary chemical contaminants.Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta.Recent Structural Insights into Cytochrome P450 Function.Fish models for environmental carcinogenesis: the rainbow trout.Site-specific targeting of aflatoxin adduction directed by triple helix formation in the major groove of oligodeoxyribonucleotides.Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.Inhibition of human cytochrome P450 3A4 by cholesterolDNA Sequence Modulates Geometrical Isomerism of the trans-8,9- Dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)- 9-hydroxy Aflatoxin B1 AdductInherent stereospecificity in the reaction of aflatoxin B(1) 8,9-epoxide with deoxyguanosine and efficiency of DNA catalysisSterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase.Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytesFood-drug interactions via human cytochrome P450 3A (CYP3A).Aspergillus nidulans verA is required for production of the mycotoxin sterigmatocystinEnergetics of heterotropic cooperativity between alpha-naphthoflavone and testosterone binding to CYP3A4Life and times in biochemical toxicology.Reaction of aflatoxin B1 exo-8,9-epoxide with DNA: kinetic analysis of covalent binding and DNA-induced hydrolysis.Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kineticsCharacterization of the genetic variation present in CYP3A4 in three South African populations.P450 and human cancer.Past and future applications of CYP450-genetic polymorphisms for biomonitoring of environmental toxicants.Bioactivation and Regioselectivity of Pig Cytochrome P450 3A29 towards Aflatoxin B₁.Psychophysiological stress: a significant parameter in drug pharmacokinetics.Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences.The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects.Cytochrome P450 forms in fish: catalytic, immunological and sequence similarities.Advanced Approaches to Model Xenobiotic Metabolism in Bacterial Genotoxicology In Vitro.P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer.
P2860
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P2860
Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver
description
1989 nî lūn-bûn
@nan
1989 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Evidence for cytochrome P-450N ...... n of aflatoxins in human liver
@ast
Evidence for cytochrome P-450N ...... n of aflatoxins in human liver
@en
Evidence for cytochrome P-450N ...... n of aflatoxins in human liver
@nl
type
label
Evidence for cytochrome P-450N ...... n of aflatoxins in human liver
@ast
Evidence for cytochrome P-450N ...... n of aflatoxins in human liver
@en
Evidence for cytochrome P-450N ...... n of aflatoxins in human liver
@nl
prefLabel
Evidence for cytochrome P-450N ...... n of aflatoxins in human liver
@ast
Evidence for cytochrome P-450N ...... n of aflatoxins in human liver
@en
Evidence for cytochrome P-450N ...... n of aflatoxins in human liver
@nl
P2860
P921
P3181
P356
P1476
Evidence for cytochrome P-450N ...... n of aflatoxins in human liver
@en
P2093
F P Guengerich
P2860
P3181
P356
10.1073/PNAS.86.2.462
P407
P577
1989-01-01T00:00:00Z