P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer.
about
Incorporating children's toxicokinetics into a risk frameworkMetabolic activation of clopidogrel: in vitro data provide conflicting evidence for the contributions of CYP2C19 and PON1Combined computational metabolite prediction and automated structure-based analysis of mass spectrometric data.Cytochrome P4501A (CYP1A) induction in rat and man by the benzodioxino derivative, fluparoxan.Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen.Predicting pharmacokinetics and drug interactions in patients from in vitro and in vivo models: the experience with 5,6-dimethylxanthenone-4-acetic acid (DMXAA), an anti-cancer drug eliminated mainly by conjugation.Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches.Computational prediction of human drug metabolism.Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivoMetabolism of melatonin by cytochrome P450s in rat liver mitochondria and microsomes.Gene expression and immunochemical localization of major cytochrome P450 drug-metabolizing enzymes in bovine nasal olfactory and respiratory mucosa.Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N'-nitrosonornicotine.Carbonated soft drinks alter hepatic cytochrome P450 isoform expression in Wistar rats.Network analysis and cross species comparison of protein-protein interaction networks of human, mouse and rat cytochrome P450 proteins that degrade xenobiotics.Studies on the toxicity of analogues of dapsone in-vitro using rat, human and heterologously expressed metabolizing systems.Effects of benzimidazole derivatives on cytochrome P450 1A1 expression in a human hepatoma cell line.Pharmacokinetics and pharmacodynamics in toxicology.Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.Dog liver microsomal P450 enzyme-mediated toluene biotransformation.The influence of ochratoxin A on DNA adduct formation by the carcinogen aristolochic acid in rats.Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significantly correlated with cytochrome P450 suppression.Species differences in the metabolism of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid in vitro: implications for prediction of metabolic interactions in vivo.Species differences in the distribution of drug-metabolizing enzymes in the pancreas.Effects of cigarette smoke with different tar contents on hepatic and pulmonary xenobiotic metabolizing enzymes in rats.DNA adduct formation by the anticancer drug ellipticine in rats determined by 32P postlabeling.Effect of simvastatin and naringenin coadministration on rat liver DNA fragmentation and cytochrome P450 activity: an in vivo and in vitro study.Characterization of cytochrome P450 (CYP3A12) induction by rifampicin in dog liver.Simultaneous and comprehensive in vivo analysis of cytochrome P450 activity by using a cocktail approach in rats.Species and sex differences of testosterone and nifedipine oxidation in liver microsomes of rat, dog and monkey.Quantitation of cytochrome P450 enzymes (CYP1A1/2, 2B11, 2C21 and 3A12) in dog liver microsomes by enzyme-linked immunosorbent assay.The effect of sepsis during parenteral nutrition on hepatic microsomal function in rats.In vitro 3-D culture demonstrates incompetence in improving maintenance ability of primary hepatocytesAn update on metabolism studies using human hepatocytes in primary culture
P2860
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P2860
P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
P450 in the rat and man: metho ...... ities and relevance to cancer.
@en
type
label
P450 in the rat and man: metho ...... ities and relevance to cancer.
@en
prefLabel
P450 in the rat and man: metho ...... ities and relevance to cancer.
@en
P2860
P1433
P1476
P450 in the rat and man: metho ...... ities and relevance to cancer.
@en
P2093
P2860
P304
P356
10.3109/00498259409038673
P407
P577
1994-12-01T00:00:00Z