about
INS-gene mutations: from genetics and beta cell biology to clinical diseaseNovel Covalently Linked Insulin Dimer Engineered to Investigate the Function of Insulin DimerizationParadoxical structure and function in a mutant human insulin associated with diabetes mellitusINSL5 is a high affinity specific agonist for GPCR142 (GPR100)Polymorphic DNA region adjacent to the 5' end of the human insulin geneA mutation in the insulin receptor gene that impairs transport of the receptor to the plasma membrane and causes insulin-resistant diabetes.Many faces of monogenic diabetesThe genetics of type 2 diabetes.Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene.Diabetes due to secretion of a structurally abnormal insulin (insulin Wakayama). Clinical and functional characteristics of [LeuA3] insulin.Structurally abnormal insulin in a diabetic patient. Characterization of the mutant insulin A3 (Val----Leu) isolated from the pancreas.Biochemical and clinical implications of proinsulin conversion intermediates.Familial hyperproinsulinemia. Two cohorts secreting indistinguishable type II intermediates of proinsulin conversion.Human insulin B24 (Phe----Ser). Secretion and metabolic clearance of the abnormal insulin in man and in a dog model.Genetically defined pancreatic beta cell failure.Human insulin prepared by recombinant DNA techniques and native human insulin interact identically with insulin receptorsLocalization of the human insulin gene to the distal end of the short arm of chromosome 11.Insulin gene mutations as a cause of permanent neonatal diabetes.[LeuB24]insulin and [AlaB24]insulin: altered structures and cellular processing of B24-substituted insulin analogs.Semisynthesis and biological activity of porcine [LeuB24]insulin and [LeuB25]insulin.Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose production.Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes.Identification of a mutant human insulin predicted to contain a serine-for-phenylalanine substitutionStudies on mutant human insulin genes: identification and sequence analysis of a gene encoding [SerB24]insulinInsulin gene mutations and diabetesComputational study of the activity, dynamics, energetics and conformations of insulin analogues using molecular dynamics simulations: Application to hyperinsulinemia and the critical residue B26.Characterization of [LeuB-24]- and [LeuB-25]-insulin analogues. Receptor binding and biological activity.Chronic intracerebroventricular administration of relaxin-3 increases body weight in rats.Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus.
P2860
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P2860
description
1979 nî lūn-bûn
@nan
1979 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1979 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1979年の論文
@ja
1979年論文
@yue
1979年論文
@zh-hant
1979年論文
@zh-hk
1979年論文
@zh-mo
1979年論文
@zh-tw
1979年论文
@wuu
name
A structurally abnormal insulin causing human diabetes
@ast
A structurally abnormal insulin causing human diabetes
@en
A structurally abnormal insulin causing human diabetes
@en-gb
A structurally abnormal insulin causing human diabetes
@nl
type
label
A structurally abnormal insulin causing human diabetes
@ast
A structurally abnormal insulin causing human diabetes
@en
A structurally abnormal insulin causing human diabetes
@en-gb
A structurally abnormal insulin causing human diabetes
@nl
prefLabel
A structurally abnormal insulin causing human diabetes
@ast
A structurally abnormal insulin causing human diabetes
@en
A structurally abnormal insulin causing human diabetes
@en-gb
A structurally abnormal insulin causing human diabetes
@nl
P2093
P2860
P356
P1433
P1476
A structurally abnormal insulin causing human diabetes
@en
P2093
A Rubenstein
M Kobayashi
O Kolterman
P2860
P2888
P356
10.1038/281122A0
P407
P577
1979-09-13T00:00:00Z
P6179
1046468684