INSL5 is a high affinity specific agonist for GPCR142 (GPR100) - Wikidata - awgldk - TriplyDB

INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

http://www.wikidata.org/entity/Q28291581

about

Using paleogenomics to study the evolution of gene families: origin and duplication history of the relaxin family hormones and their receptors Evolution of the relaxin-like peptide family New insights into ligand-receptor pairing and coevolution of relaxin family peptides and their receptors in teleosts The electrostatic interactions of relaxin-3 with receptor RXFP4 and the influence of its B-chain C-terminal conformation Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways Structure of the R3/I5 Chimeric Relaxin Peptide, a Selective GPCR135 and GPCR142 Agonist 7α, 25-dihydroxycholesterol-mediated activation of EBI2 in immune regulation and diseases Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency Insulin-like peptide 5 is an orexigenic gastrointestinal hormone Relaxin-3-deficient mice showed slight alteration in anxiety-related behavior.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors A relaxin-like peptide purified from radial nerves induces oocyte maturation and ovulation in the starfish, Asterina pectinifera.Development of a selective agonist for relaxin family peptide receptor 3.Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3.International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.Constitutive formation of an RXFP1-signalosome: a novel paradigm in GPCR function and regulation.An insulin-like peptide regulates egg maturation and metabolism in the mosquito Aedes aegypti.Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose production.Relaxin as a natural agent for vascular health Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4 Relaxin-3/RXFP3 Signaling and Neuroendocrine Function - A Perspective on Extrinsic Hypothalamic Control.Relaxin family peptide systems and the central nervous system.A novel BRET-based binding assay for interaction studies of relaxin family peptide receptor 3 with its ligands.Distribution, physiology and pharmacology of relaxin-3/RXFP3 systems in brain.The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo.Relaxin family peptides: structure-activity relationship studies.Secretory overexpression and isotopic labeling of the chimeric relaxin family peptide R3/I5 in Pichia pastoris.A convenient method for europium-labeling of a recombinant chimeric relaxin family peptide R3/I5 for receptor-binding assays.Site-specific DOTA/europium-labeling of recombinant human relaxin-3 for receptor-ligand interaction studies.Probing the functional domains of relaxin-3 and the creation of a selective antagonist for RXFP3/GPCR135 over relaxin receptor RXFP1/LGR7.Structural properties of relaxin chimeras.Relaxin signaling from natural receptors.Synthesis, conformation, and activity of human insulin-like peptide 5 (INSL5).The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling.The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3.Design and recombinant expression of insulin-like peptide 5 precursors and the preparation of mature human INSL5.R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization.Structural insights into the function of relaxins.Recombinant expression of an insulin-like peptide 3 (INSL3) precursor and its enzymatic conversion to mature human INSL3.

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P2860

INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

http://www.wikidata.org/entity/Q28291581

description

2005 nî lūn-bûn

@nan

2005 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2005年の論文

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2005年論文

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2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

@ast

INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

@en

INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

@nl

type

label

INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

@ast

INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

@en

INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

@nl

prefLabel

INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

@ast

INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

@en

INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

@nl

P1433

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Journal of Biological Chemistry

P1476

INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

@en

P2093

Changlu Liu

http://www.w3.org/2001/XMLSchema#string

Chester Kuei

http://www.w3.org/2001/XMLSchema#string

Da-Thao Tran

http://www.w3.org/2001/XMLSchema#string

Diane Nepomuceno

http://www.w3.org/2001/XMLSchema#string

Elo Eriste

http://www.w3.org/2001/XMLSchema#string

Fredrik Kamme

http://www.w3.org/2001/XMLSchema#string

Jessica Zhu

http://www.w3.org/2001/XMLSchema#string

Jiejun Wu

http://www.w3.org/2001/XMLSchema#string

Jingcai Chen

http://www.w3.org/2001/XMLSchema#string

Pascal Bonaventure

http://www.w3.org/2001/XMLSchema#string

P2860

Activation of orphan receptors by the hormone relaxin

A structurally abnormal insulin causing human diabetes

Structure of a genomic clone encoding biologically active human relaxin

Molecular characterization and in vitro biological activity of placentin, a new member of the insulin gene family

The disulphide bonds of insulin

H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2

Identification of relaxin-3/INSL7 as a ligand for GPCR142

Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135

Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7

Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family

P304

292-300

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scholarly article

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142780

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P356

10.1074/JBC.M409916200

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P433

1

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280

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P577

2005-01-07T00:00:00Z

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15525639

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P921

G protein-coupled receptor