Differences in regulatory properties between human and rat glucokinase regulatory protein
about
Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrationsSuccinate dehydrogenase flavoprotein subunit expression in Saccharomyces cerevisiae--involvement of the mitochondrial FAD transporter, Flx1p.Functional characterization of MODY2 mutations highlights the importance of the fine-tuning of glucokinase and its role in glucose sensingA panel of diverse assays to interrogate the interaction between glucokinase and glucokinase regulatory protein, two vital proteins in human diseaseGlucotoxicity targets hepatic glucokinase in Zucker diabetic fatty rats, a model of type 2 diabetes associated with obesity.Standardized extract of Ficus deltoidea stimulates insulin secretion and blocks hepatic glucose production by regulating the expression of glucose-metabolic genes in streptozitocin-induced diabetic rats.Analysis of the co-operative interaction between the allosterically regulated proteins GK and GKRP using tryptophan fluorescenceCellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk.Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism.Identification and functional characterisation of novel glucokinase mutations causing maturity-onset diabetes of the young in Slovakia.The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein: impact of physiological and pharmacological effectors.Discovery of a novel site regulating glucokinase activity following characterization of a new mutation causing hyperinsulinemic hypoglycemia in humansGlucokinase regulatory protein: complexity at the crossroads of triglyceride and glucose metabolism.The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis.Evolution of vertebrate glucokinase regulatory protein from a bacterial N-acetylmuramate 6-phosphate etherase.Pharmacodynamic effects of the oral glucokinase activator AZD6370 after single doses in healthy volunteers assessed with euglycaemic clamp.Regulation of Glucokinase by Glucokinase Regulatory Proteinglucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complexcytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP)A defect in glucose-induced dissociation of glucokinase from the regulatory protein in Zucker diabetic fatty rats in the early stage of diabetes.Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia
P2860
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P2860
Differences in regulatory properties between human and rat glucokinase regulatory protein
description
2004 nî lūn-bûn
@nan
2004 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մարտին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Differences in regulatory properties between human and rat glucokinase regulatory protein
@ast
Differences in regulatory properties between human and rat glucokinase regulatory protein
@en
Differences in regulatory properties between human and rat glucokinase regulatory protein
@en-gb
Differences in regulatory properties between human and rat glucokinase regulatory protein
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type
label
Differences in regulatory properties between human and rat glucokinase regulatory protein
@ast
Differences in regulatory properties between human and rat glucokinase regulatory protein
@en
Differences in regulatory properties between human and rat glucokinase regulatory protein
@en-gb
Differences in regulatory properties between human and rat glucokinase regulatory protein
@nl
prefLabel
Differences in regulatory properties between human and rat glucokinase regulatory protein
@ast
Differences in regulatory properties between human and rat glucokinase regulatory protein
@en
Differences in regulatory properties between human and rat glucokinase regulatory protein
@en-gb
Differences in regulatory properties between human and rat glucokinase regulatory protein
@nl
P2093
P2860
P921
P356
P1433
P1476
Differences in regulatory properties between human and rat glucokinase regulatory protein
@en
P2093
Katy J Brocklehurst
Loranne Agius
Rick A Davies
P2860
P356
10.1042/BJ20031414
P407
P577
2004-03-01T00:00:00Z