The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.
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Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrationsAssociation of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC StudyGlucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention studyInteraction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescentsChronic alcohol consumption potentiates the development of diabetes through pancreatic β-cell dysfunctionNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskTrans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivityGlucokinase regulatory protein genetic variant interacts with omega-3 PUFA to influence insulin resistance and inflammation in metabolic syndromePersonal omics profiling reveals dynamic molecular and medical phenotypesAssociations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control studyA genome-wide perspective of genetic variation in human metabolism.Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.Effects of MK-0941, a novel glucokinase activator, on glycemic control in insulin-treated patients with type 2 diabetesThe association between Mediterranean Diet Score and glucokinase regulatory protein gene variation on the markers of cardiometabolic risk: an analysis in the European Prospective Investigation into Cancer (EPIC)-Norfolk studyChronic ethanol consumption-induced pancreatic {beta}-cell dysfunction and apoptosis through glucokinase nitration and its down-regulation.Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness?Serum uric acid levels are associated with polymorphisms in the SLC2A9, SF1, and GCKR genes in a Chinese populationGenetic determinants of plasma triglyceridesGCKR variants increase triglycerides while protecting from insulin resistance in Chinese childrenMendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance.Causal relationship between adiponectin and metabolic traits: a Mendelian randomization study in a multiethnic population.Large scale meta-analyses of fasting plasma glucose raising variants in GCK, GCKR, MTNR1B and G6PC2 and their impacts on type 2 diabetes mellitus risk.Associations between a polymorphism in the pleiotropic GCKR and Age-related phenotypes: the HALCyon programme.Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.Variants of GCKR affect both β-cell and kidney function in patients with newly diagnosed type 2 diabetes: the Verona newly diagnosed type 2 diabetes study 2.A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort.Characterization of a novel glucokinase activator in rat and mouse modelsPersonalized sequencing and the future of medicine: discovery, diagnosis and defeat of disease.World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease: part 3.Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphismGlucokinase regulatory protein: complexity at the crossroads of triglyceride and glucose metabolism.Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males: a case-control study.Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men.Genetic variants, prediagnostic circulating levels of insulin-like growth factors, insulin, and glucose and the risk of colorectal cancer: the Multiethnic Cohort study.Polymorphisms in the GCKR are associated with serum lipid traits, the risk of coronary artery disease and ischemic stroke.Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish menGenome-wide association studies with metabolomics.Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China
P2860
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P2860
The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The common P446L polymorphism ...... ive general French population.
@ast
The common P446L polymorphism ...... ive general French population.
@en
The common P446L polymorphism ...... ive general French population.
@nl
type
label
The common P446L polymorphism ...... ive general French population.
@ast
The common P446L polymorphism ...... ive general French population.
@en
The common P446L polymorphism ...... ive general French population.
@nl
prefLabel
The common P446L polymorphism ...... ive general French population.
@ast
The common P446L polymorphism ...... ive general French population.
@en
The common P446L polymorphism ...... ive general French population.
@nl
P2093
P2860
P50
P356
P1433
P1476
The common P446L polymorphism ...... ive general French population.
@en
P2093
Aurélie Dechaume
Beverley Balkau
DESIR Study Group
Jean Tichet
Martine Vaxillaire
P2860
P304
P356
10.2337/DB07-1807
P407
P577
2008-06-12T00:00:00Z