A novel GRK2/HDAC6 interaction modulates cell spreading and motility
about
Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processesSpecific in vivo labeling of tyrosinated α-tubulin and measurement of microtubule dynamics using a GFP tagged, cytoplasmically expressed recombinant antibodyPaxillin inhibits HDAC6 to regulate microtubule acetylation, Golgi structure, and polarized migration.Luminal localization of α-tubulin K40 acetylation by cryo-EM analysis of fab-labeled microtubules.Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2.Histone deacetylase 6 is a FoxO transcription factor-dependent effector in skeletal muscle atrophy.aPKC phosphorylation of HDAC6 results in increased deacetylation activityEGF-induced sodium influx regulates EGFR trafficking through HDAC6 and tubulin acetylation.Rho-associated coiled-coil kinase (ROCK) protein controls microtubule dynamics in a novel signaling pathway that regulates cell migrationGRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance.HDAC6 and ovarian cancer.Cigarette Smoke Disrupted Lung Endothelial Barrier Integrity and Increased Susceptibility to Acute Lung Injury via Histone Deacetylase 6Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migrationG Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 AxisDido3-dependent HDAC6 targeting controls cilium size.Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis.Multiple functions of G protein-coupled receptor kinasesFeedback regulation of G protein-coupled receptor signaling by GRKs and arrestins.Limited efficacy of specific HDAC6 inhibition in urothelial cancer cells.Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex.Bioimpedance rise in response to histone deacetylase inhibitor is a marker of mammary cancer cells within a mixed culture of normal breast cells.Human histone deacetylase 6 shows strong preference for tubulin dimers over assembled microtubules.Histone deacetylase 6 activity is critical for the metastasis of Burkitt's lymphoma cells.The interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility.HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes.G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling.G protein coupled-receptor signaling and reversible lysine acetylation.Paxillin regulates cell polarization and anterograde vesicle trafficking during cell migration.Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2.Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug targetHistone deacetylase 6 in cancerPin1 Is Involved in HDAC6-mediated Cancer Cell Motility
P2860
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P2860
A novel GRK2/HDAC6 interaction modulates cell spreading and motility
description
2012 nî lūn-bûn
@nan
2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
A novel GRK2/HDAC6 interaction modulates cell spreading and motility
@ast
A novel GRK2/HDAC6 interaction modulates cell spreading and motility
@en
A novel GRK2/HDAC6 interaction modulates cell spreading and motility
@en-gb
A novel GRK2/HDAC6 interaction modulates cell spreading and motility
@nl
type
label
A novel GRK2/HDAC6 interaction modulates cell spreading and motility
@ast
A novel GRK2/HDAC6 interaction modulates cell spreading and motility
@en
A novel GRK2/HDAC6 interaction modulates cell spreading and motility
@en-gb
A novel GRK2/HDAC6 interaction modulates cell spreading and motility
@nl
prefLabel
A novel GRK2/HDAC6 interaction modulates cell spreading and motility
@ast
A novel GRK2/HDAC6 interaction modulates cell spreading and motility
@en
A novel GRK2/HDAC6 interaction modulates cell spreading and motility
@en-gb
A novel GRK2/HDAC6 interaction modulates cell spreading and motility
@nl
P2093
P2860
P356
P1433
P1476
A novel GRK2/HDAC6 interaction modulates cell spreading and motility
@en
P2093
Federico Mayor
Ivette Aymerich
Olga Tapia
Petronila Penela
Vanesa Lafarga
P2860
P304
P356
10.1038/EMBOJ.2011.466
P407
P577
2012-02-15T00:00:00Z