about
MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cellsCHK2 kinase expression is down-regulated due to promoter methylation in non-small cell lung cancerE2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domainsImpaired DNA damage checkpoint response in MIF-deficient miceInteractions between E2F1 and SirT1 regulate apoptotic response to DNA damageDNA-damage-responsive acetylation of pRb regulates binding to E2F-1Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damageArginine methylation controls growth regulation by E2F-1DNA-damage response control of E2F7 and E2F8E2F1 induces p19INK4d, a protein involved in the DNA damage response, following UV irradiationChk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genesRegulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damageThe candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1Regulation of E2F1 function by the nuclear corepressor KAP1Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stressATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damageTopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survivalImplication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage responseIrofulven induces replication-dependent CHK2 activation related to p53 statusSelection of novel mediators of E2F1-induced apoptosis through retroviral expression of an antisense cDNA libraryDNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosisTo live or let die - complexity within the E2F1 pathwayInhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathwayStructural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repairFragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2Arginine methylation regulates the p53 responseEDD mediates DNA damage-induced activation of CHK2Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphataseControl of cell cycle transcription during G1 and S phasesDNA damage response induced by tobacco smoke in normal human bronchial epithelial and A549 pulmonary adenocarcinoma cells assessed by laser scanning cytometryCHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancerHuman papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation14-3-3 proteins integrate E2F activity with the DNA damage response.Tumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cellsTargeting of Chk2 as a countermeasure to dose-limiting toxicity triggered by topoisomerase-II (TOP2) poisonsXenopus Cds1 is regulated by DNA-dependent protein kinase and ATR during the cell cycle checkpoint response to double-stranded DNA endsDNA IR-Double Strand Breaks (DSBs) and cellular response via ATMCell cycle-dependent localization of CHK2 at centrosomes during mitosis.Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Chk2 activates E2F-1 in response to DNA damage
@ast
Chk2 activates E2F-1 in response to DNA damage
@en
Chk2 activates E2F-1 in response to DNA damage
@en-gb
Chk2 activates E2F-1 in response to DNA damage
@nl
type
label
Chk2 activates E2F-1 in response to DNA damage
@ast
Chk2 activates E2F-1 in response to DNA damage
@en
Chk2 activates E2F-1 in response to DNA damage
@en-gb
Chk2 activates E2F-1 in response to DNA damage
@nl
prefLabel
Chk2 activates E2F-1 in response to DNA damage
@ast
Chk2 activates E2F-1 in response to DNA damage
@en
Chk2 activates E2F-1 in response to DNA damage
@en-gb
Chk2 activates E2F-1 in response to DNA damage
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Chk2 activates E2F-1 in response to DNA damage
@en
P2093
Craig Stevens
Linda Smith
Nicholas B La Thangue
P2860
P2888
P3181
P356
10.1038/NCB974
P407
P577
2003-05-01T00:00:00Z
P6179
1052208724