Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme
about
The generation and function of soluble apoE receptors in the CNSQuantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's diseaseSorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta productionGGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β productionLipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's diseaseThe genetics and neuropathology of Alzheimer's diseaseSorting through the roles of beclin 1 in microglia and neurodegenerationRisk factor SORL1: from genetic association to functional validation in Alzheimer's diseaseInteraction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's diseaseSortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesisProteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing.Beta-secretase: structure, function, and evolution.Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.Multi-compartmental modeling of SORLA's influence on amyloidogenic processing in Alzheimer's diseaseNeuronal LR11 expression does not differentiate between clinically-defined Alzheimer's disease and control brainsAlzheimer's disease risk genes and mechanisms of disease pathogenesisDysregulation of protein trafficking in neurodegeneration.A membrane proximal helix in the cytosolic domain of the human APP interacting protein LR11/SorLA deforms liposomes.Amyloid-Beta interaction with mitochondriaThe intracellular domain of sortilin interacts with amyloid precursor protein and regulates its lysosomal and lipid raft traffickingBacterial expression, purification, and model membrane reconstitution of the transmembrane and cytoplasmic domains of the human APP binding protein LR11/SorLA for NMR studies.BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family.Sortilin associates with transforming growth factor-beta family proteins to enhance lysosome-mediated degradation.Physiology and pathology of endosome-to-Golgi retrograde sorting.Schisandrin B protects PC12 cells by decreasing the expression of amyloid precursor protein and vacuolar protein sorting 35.Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP-SorLA Interaction.Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein.The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics.ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity.Identification of Alzheimer disease-associated variants in genes that regulate retromer functionThe amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism.Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688The Alzheimer's disease beta-secretase enzyme, BACE1.The role of intracellular trafficking and the VPS10d receptors in Alzheimer's disease.Quantification of ortholog losses in insects and vertebrates.
P2860
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P2860
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Interaction of the cytosolic d ...... beta-site APP-cleaving enzyme
@ast
Interaction of the cytosolic d ...... beta-site APP-cleaving enzyme
@en
Interaction of the cytosolic d ...... beta-site APP-cleaving enzyme
@en-gb
Interaction of the cytosolic d ...... beta-site APP-cleaving enzyme
@nl
type
label
Interaction of the cytosolic d ...... beta-site APP-cleaving enzyme
@ast
Interaction of the cytosolic d ...... beta-site APP-cleaving enzyme
@en
Interaction of the cytosolic d ...... beta-site APP-cleaving enzyme
@en-gb
Interaction of the cytosolic d ...... beta-site APP-cleaving enzyme
@nl
prefLabel
Interaction of the cytosolic d ...... beta-site APP-cleaving enzyme
@ast
Interaction of the cytosolic d ...... beta-site APP-cleaving enzyme
@en
Interaction of the cytosolic d ...... beta-site APP-cleaving enzyme
@en-gb
Interaction of the cytosolic d ...... beta-site APP-cleaving enzyme
@nl
P2093
P50
P921
P3181
P1476
Interaction of the cytosolic d ...... beta-site APP-cleaving enzyme
@en
P2093
Anne V Thomas
Bradley T Hyman
Christine A F von Arnim
Michael C Irizarry
Mirjam Koker
Robert Spoelgen
P304
P3181
P356
10.1523/JNEUROSCI.3882-05.2006
P407
P577
2006-01-11T00:00:00Z