Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. - Wikidata - awgldk - TriplyDB

Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.

Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.

http://www.wikidata.org/entity/Q35743094

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Human-specific histone methylation signatures at transcription start sites in prefrontal neurons Genetics of late-onset Alzheimer's disease: update from the alzgene database and analysis of shared pathways Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction Diabetes Mellitus Induces Alzheimer's Disease Pathology: Histopathological Evidence from Animal Models Role of the Retromer Complex in Neurodegenerative Diseases Type 2 diabetes and cognitive impairment: linking mechanisms Trafficking regulation of proteins in Alzheimer's disease The retromer complex - endosomal protein recycling and beyond Sorting through the roles of beclin 1 in microglia and neurodegeneration Dynamin 1 regulates amyloid generation through modulation of BACE-1 Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction Genetic signatures of exceptional longevity in humans SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease Toward the treatment and prevention of Alzheimer's disease: rational strategies and recent progress Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice.The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.Vps35 haploinsufficiency results in degenerative-like deficit in mouse retinal ganglion neurons and impairment of optic nerve injury-induced gliosis.Pharmacological chaperones stabilize retromer to limit APP processing.SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells.BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.Apomorphine and Alzheimer Aβ: roles for regulated α cleavage, autophagy, and antioxidation?Physiology and pathology of endosome-to-Golgi retrograde sorting.The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.Identifying quantitative trait loci via group-sparse multitask regression and feature selection: an imaging genetics study of the ADNI cohort.Alzheimer's disease and the amyloid cascade hypothesis: a critical review.SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways Epidemiology of Alzheimer disease.Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome.Identification of Alzheimer disease-associated variants in genes that regulate retromer function Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.Beclin 1 regulates neuronal transforming growth factor-β signaling by mediating recycling of the type I receptor ALK5.LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease.The role of intracellular trafficking and the VPS10d receptors in Alzheimer's disease.Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1 Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes.Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-β peptide Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.

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Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.

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2010年论文

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2010年论文

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Diabetes-associated SorCS1 reg ...... orL1 and the retromer complex.

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Diabetes-associated SorCS1 reg ...... orL1 and the retromer complex.

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Diabetes-associated SorCS1 reg ...... orL1 and the retromer complex.

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Diabetes-associated SorCS1 reg ...... orL1 and the retromer complex.

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Diabetes-associated SorCS1 reg ...... orL1 and the retromer complex.

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JNEUROSCI.3872-10.2010

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Journal of Neuroscience

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Diabetes-associated SorCS1 reg ...... orL1 and the retromer complex.

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Alan D Attie

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James A Lah

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John W Steele

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Michelle E Ehrlich

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Rachel F Lane

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Sam Gandy

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Scott A Small

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Summer M Raines

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P2860

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells

A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

Loss of apolipoprotein E receptor LR11 in Alzheimer disease

The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments

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13110-13115

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scholarly article

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10.1523/JNEUROSCI.3872-10.2010

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39

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30

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Rudolph E. Tanzi

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2010-09-01T00:00:00Z

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46820418

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20881129

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Alzheimer's disease

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3274732

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