Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein
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miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOTThe interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targetsTwo PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencingMolecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding proteinGW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylationLa-Related Protein 4 Binds Poly(A), Interacts with the Poly(A)-Binding Protein MLLE Domain via a Variant PAM2w Motif, and Can Promote mRNA StabilityCharacterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus ReplicationAtaxin-2: From RNA Control to Human Health and DiseaseInsights into the evolution and domain structure of Ataxin-2 proteins across eukaryotesThe mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.The complexity of miRNA-mediated repressionHPat a decapping activator interacting with the miRNA effector complex.A role for the poly(A)-binding protein Pab1p in PUF protein-mediated repression.Makorin ring zinc finger protein 1 (MKRN1), a novel poly(A)-binding protein-interacting protein, stimulates translation in nerve cells.The multifunctional poly(A)-binding protein (PABP) 1 is subject to extensive dynamic post-translational modification, which molecular modelling suggests plays an important role in co-ordinating its activities.The MLLE domain of the ubiquitin ligase UBR5 binds to its catalytic domain to regulate substrate binding.The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes.A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAs.The miRNA biogenesis in marine bivalves.Spinocerebellar ataxia type 2: clinical presentation, molecular mechanisms, and therapeutic perspectives.The decapping activator HPat a novel factor co-purifying with GW182 from Drosophila cells.Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.miRNA repression of translation in vitro takes place during 43S ribosomal scanning.Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha.Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus.mRNA transport in fungal top models.PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding.Structural Foundations of RNA Silencing by Argonaute.Effects of the enlargement of polyglutamine segments on the structure and folding of ataxin-2 and ataxin-3 proteins.Control of CNS functions by RNA-binding proteins in neurological diseases
P2860
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P2860
Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein
description
2010 nî lūn-bûn
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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
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Structural basis of binding of ...... ain of poly(A)-binding protein
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P2860
P356
P1476
Structural basis of binding of ...... ain of poly(A)-binding protein
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P2093
Angelika Rosenauer
Nozhat Safaee
P2860
P304
P356
10.1074/JBC.M109.089540
P407
P577
2010-04-30T00:00:00Z