A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
about
The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint SignalingCell division: control of the chromosomal passenger complex in time and spacePhosphorylation of threonine 3 on histone H3 by haspin kinase is required for meiosis I in mouse oocytesModulation of the Chromatin Phosphoproteome by the Haspin Protein KinaseEB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B.Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice.Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregationRequirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpointProbing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524.H3 Thr3 phosphorylation is crucial for meiotic resumption and anaphase onset in oocyte meiosis.Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.Pds5B is required for cohesion establishment and Aurora B accumulation at centromeresAutoinhibition and Polo-dependent multisite phosphorylation restrict activity of the histone H3 kinase Haspin to mitosis.Polo-like kinase-1 triggers histone phosphorylation by Haspin in mitosis.Haspin inhibition reveals functional differences of interchromatid axis-localized AURKB and AURKC.Plk1 puts a (Has)pin on the mitotic histone code.Co-crystal structures of the protein kinase haspin with bisubstrate inhibitors.Haspin kinase regulates microtubule-organizing center clustering and stability through Aurora kinase C in mouse oocytes.Borealin dimerization mediates optimal CPC checkpoint function by enhancing localization to centromeres and kinetochores.The Ska complex promotes Aurora B activity to ensure chromosome biorientation.Anti-Melanoma Activities of Haspin Inhibitor CHR-6494 Deployed as a Single Agent or in a Synergistic Combination with MEK Inhibitor.PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencingDNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes.The Ins and Outs of Aurora B Inner Centromere Localization.Haspin has Multiple Functions in the Plant Cell Division Regulatory Network.VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis.A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion.Chromosome segregation regulation in human zygotes: altered mitotic histone phosphorylation dynamics underlying centromeric targeting of the chromosomal passenger complex.Slowly on, Slowly off: Bisubstrate-Analogue Conjugates of 5-Iodotubercidin and Histone H3 Peptide Targeting Protein Kinase Haspin.3H-pyrazolo[4,3-f]quinoline haspin kinase inhibitors and anticancer properties.Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80
P2860
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P2860
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
description
2012 nî lūn-bûn
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2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
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name
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
@ast
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
@en
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
@en-gb
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
@nl
type
label
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
@ast
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
@en
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
@en-gb
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
@nl
prefLabel
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
@ast
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
@en
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
@en-gb
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
@nl
P2860
P50
P921
P356
P1476
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
@en
P2093
Anna De Antoni
Stefano Maffini
P2860
P304
P356
10.1083/JCB.201205119
P407
P577
2012-10-15T00:00:00Z