Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)
about
S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethalityPhosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cellsMolecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunctionTurnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosisInsulin receptor signaling in normal and insulin-resistant statesLipidomics-Reshaping the Analysis and Perception of Type 2 DiabetesRegulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2The effects of obesity on skeletal muscle regenerationComputer-aided targeting of the PI3K/Akt/mTOR pathway: toxicity reduction and therapeutic opportunitiesElevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and εMechanisms for insulin resistance: common threads and missing linksInhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol.Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation.Exercise and Glycemic Control: Focus on Redox Homeostasis and Redox-Sensitive Protein Signaling.Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humansThe role of oxidative stress in the pathogenesis of type 2 diabetes: from molecular mechanism to clinical implication.Visualization of dynamic change in contraction-induced lipid composition in mouse skeletal muscle by matrix-assisted laser desorption/ionization imaging mass spectrometry.Palmitate-induced down-regulation of sortilin and impaired GLUT4 trafficking in C2C12 myotubes.Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance.Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker ratsSuppression of protein kinase C theta contributes to enhanced myogenesis in vitro via IRS1 and ERK1/2 phosphorylationAltered skeletal muscle lipase expression and activity contribute to insulin resistance in humans.Insulin resistance and muscle insulin receptor substrate-1 serine hyperphosphorylation.Continued postnatal administration of resveratrol prevents diet-induced metabolic syndrome in rat offspring born growth restricted.Delta-like 1/fetal antigen-1 (Dlk1/FA1) is a novel regulator of chondrogenic cell differentiation via inhibition of the Akt kinase-dependent pathwayDeep proteomics of mouse skeletal muscle enables quantitation of protein isoforms, metabolic pathways, and transcription factors.The metabolic footprint of aging in micePKCθ activation in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters and growth factors is needed for stimulation of numerous important cellular signaling cascades.High-fat load: mechanism(s) of insulin resistance in skeletal muscle.Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K).Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistanceMuscle-specific knock-out of NUAK family SNF1-like kinase 1 (NUAK1) prevents high fat diet-induced glucose intoleranceReversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes.DAG tales: the multiple faces of diacylglycerol--stereochemistry, metabolism, and signalingMolecular approach to identify antidiabetic potential of Azadirachta indicaActivation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity.The effect of exercise-intensity on skeletal muscle stress kinase and insulin protein signaling.TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells.
P2860
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P2860
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)
@ast
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)
@en
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)
@nl
type
label
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)
@ast
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)
@en
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)
@nl
prefLabel
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)
@ast
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)
@en
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)
@nl
P2093
P921
P3181
P356
P1476
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)
@en
P2093
Dan R Littman
Roberto D Polakiewicz
Timothy J Soos
Xiaojian Sun
Xinghai Li
P304
45304-45307
P3181
P356
10.1074/JBC.C400186200
P407
P577
2004-09-10T00:00:00Z