Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2
about
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repressionPRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferationS6K1 plays a critical role in early adipocyte differentiationAn emerging role for TOR signaling in mammalian tissue and stem cell physiologymTOR: from growth signal integration to cancer, diabetes and ageingmTOR signaling in growth control and diseaseCentral role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndromeSirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular EffectsLost in translation: endoplasmic reticulum stress and the decline of β-cell health in diabetes mellitusNutrient sensing, metabolism, and cell growth controlLeft-right asymmetry in the light of TOR: An update on what we know so farRegulation of translation initiation in eukaryotes: mechanisms and biological targetsmTOR signaling in tumorigenesisTranslational control of nociception via 4E-binding protein 1eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcriptionRegulation of the mTOR complex 1 pathway by nutrients, growth factors, and stressIncreased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice.Parallel measurement of dynamic changes in translation rates in single cells.Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.The metabolic syndromeOxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage.mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.Disruption of genes encoding eIF4E binding proteins-1 and -2 does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice.Ribosomal protein S6 kinase is a critical downstream effector of the target of rapamycin complex 1 for long-term facilitation in Aplysia.Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation.Proteomic analysis of ribosomes: translational control of mRNA populations by glycogen synthase GYS1.eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression.The aging stress response.DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.mTOR signaling for biological control and cancer.Regulation of mTORC1 and its impact on gene expression at a glance.eIF4EBP3L acts as a gatekeeper of TORC1 in activity-dependent muscle growth by specifically regulating Mef2ca translational initiation.Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models.Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice.Promyelocytic leukemia inhibits adipogenesis, and loss of promyelocytic leukemia results in fat accumulation in mice.A link between protein translation and body weight.Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells4E-BPs Control Fat Storage by Regulating the Expression of Egr1 and ATGL
P2860
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P2860
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2
description
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im Februar 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/02/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/02/01)
@nl
наукова стаття, опублікована в лютому 2007
@uk
مقالة علمية (نشرت في فبراير 2007)
@ar
name
Elevated sensitivity to diet-i ...... mice lacking 4E-BP1 and 4E-BP2
@ast
Elevated sensitivity to diet-i ...... mice lacking 4E-BP1 and 4E-BP2
@en
Elevated sensitivity to diet-i ...... mice lacking 4E-BP1 and 4E-BP2
@nl
type
label
Elevated sensitivity to diet-i ...... mice lacking 4E-BP1 and 4E-BP2
@ast
Elevated sensitivity to diet-i ...... mice lacking 4E-BP1 and 4E-BP2
@en
Elevated sensitivity to diet-i ...... mice lacking 4E-BP1 and 4E-BP2
@nl
prefLabel
Elevated sensitivity to diet-i ...... mice lacking 4E-BP1 and 4E-BP2
@ast
Elevated sensitivity to diet-i ...... mice lacking 4E-BP1 and 4E-BP2
@en
Elevated sensitivity to diet-i ...... mice lacking 4E-BP1 and 4E-BP2
@nl
P2093
P2860
P921
P3181
P356
P1476
Elevated sensitivity to diet-i ...... mice lacking 4E-BP1 and 4E-BP2
@en
P2093
Denis Richard
Emmanuel Petroulakis
Francis Poulin
Olivier Le Bacquer
Sabina Paglialunga
P2860
P304
P3181
P356
10.1172/JCI29528
P407
P577
2007-02-01T00:00:00Z