Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy
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Targets for therapy in sarcomeric cardiomyopathiesResearch priorities in sarcomeric cardiomyopathiesWhy Is there a Limit to the Changes in Myofilament Ca2+-Sensitivity Associated with Myopathy Causing Mutations?Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin TThe molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathyDecreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin TThe pathogenesis of ACTA1-related congenital fiber type disproportion.The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.Cardiac troponin T (TNNT2) mutations in chinese dilated cardiomyopathy patientsMolecular etiology of idiopathic cardiomyopathy.Recurrent and founder mutations in the Netherlands: mutation p.K217del in troponin T2, causing dilated cardiomyopathy.Virus-induced dilated cardiomyopathy is characterized by increased levels of fibrotic extracellular matrix proteins and reduced amounts of energy-producing enzymes.Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy.Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin.Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.Cardiac troponin T and familial hypertrophic cardiomyopathy: an energetic affairInsights into restrictive cardiomyopathy from clinical and animal studies.The miscommunicative cardiac cell: when good proteins go bad.Myocardial regulatory proteins and heart failure.Significance of troponin dynamics for Ca2+-mediated regulation of contraction and inherited cardiomyopathy.Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies.Genetics of dilated cardiomyopathy.Structural and functional consequences of cardiac troponin C L57Q and I61Q Ca(2+)-desensitizing variantsMutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation.Troponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: increased or decreased?An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivityCardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death.Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples.Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants-Genotype to Cellular Phenotype.How do mutations in contractile proteins cause the primary familial cardiomyopathies?Inherited cardiomyopathies caused by troponin mutations.Hypertrophic cardiomyopathy: how do mutations lead to disease?Biochemical characterisation of Troponin C mutations causing hypertrophic and dilated cardiomyopathies.Molecular mechanisms of sarcomere dysfunction in dilated and hypertrophic cardiomyopathy.TNNT2 gene polymorphisms are associated with susceptibility to idiopathic dilated cardiomyopathy in the Han Chinese population.Familial hypertrophic cardiomyopathy: functional variance among individual cardiomyocytes as a trigger of FHC-phenotype development.The Delta 14 mutation of human cardiac troponin T enhances ATPase activity and alters the cooperative binding of S1-ADP to regulated actin.Which way to grow? Force over time may be the heart's Dao de jing.Effects of troponin C isoform on the action of the cardiotonic agent EMD 57033.Phenotypic plasticity of sarcomeric protein mutations
P2860
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P2860
Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Alterations in thin filament r ...... se hypertrophic cardiomyopathy
@ast
Alterations in thin filament r ...... se hypertrophic cardiomyopathy
@en
Alterations in thin filament r ...... se hypertrophic cardiomyopathy
@en-gb
Alterations in thin filament r ...... se hypertrophic cardiomyopathy
@nl
type
label
Alterations in thin filament r ...... se hypertrophic cardiomyopathy
@ast
Alterations in thin filament r ...... se hypertrophic cardiomyopathy
@en
Alterations in thin filament r ...... se hypertrophic cardiomyopathy
@en-gb
Alterations in thin filament r ...... se hypertrophic cardiomyopathy
@nl
prefLabel
Alterations in thin filament r ...... se hypertrophic cardiomyopathy
@ast
Alterations in thin filament r ...... se hypertrophic cardiomyopathy
@en
Alterations in thin filament r ...... se hypertrophic cardiomyopathy
@en-gb
Alterations in thin filament r ...... se hypertrophic cardiomyopathy
@nl
P2093
P3181
P356
P1476
Alterations in thin filament r ...... se hypertrophic cardiomyopathy
@en
P2093
Adam Knott
Charles Redwood
Hassan Abdulrazzak
Mahmooda Mirza
Paul Robinson
Ruth Willott
Steven Marston
P304
P3181
P356
10.1074/JBC.M203446200
P407
P577
2002-10-25T00:00:00Z