RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene
about
The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathwaysSignal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1uThe sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavageThe TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ERA palindrome-driven complex rearrangement of 22q11.2 and 8q24.1 elucidated using novel technologiesUbe2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates.The Unfolded Protein Response, Degradation from Endoplasmic Reticulum and CancerViral and cellular MARCH ubiquitin ligases and cancer.Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradationGlioblastomas with copy number gains in EGFR and RNF139 show increased expressions of carbonic anhydrase genes transformed by ENO1.A Ubc7p-binding domain in Cue1p activates ER-associated protein degradation.Porcine JAB1 significantly enhances apoptosis induced by staurosporine.The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma.Degradation of sterol regulatory element-binding protein precursor requires the endoplasmic reticulum-associated degradation components Ubc7 and Hrd1 in fission yeastG6PC3, ALDOA and CS induction accompanies mir-122 down-regulation in the mechanical asphyxia and can serve as hypoxia biomarkers.TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation.Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels.A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G(1) cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors.
P2860
Q24294805-71860C1C-1337-4FE3-B5FE-E3E71B09BCEAQ24304271-705C2C15-1B05-41CB-872A-C5624B91AD06Q24309325-2CE007E4-EF99-4D40-88F9-735F91816B1EQ24311488-CD66D5F3-E8AE-4377-8B25-0344AAFAC459Q33277820-6F559318-8F95-4717-A0C9-CF23F7CF8E75Q33590955-8F2CA9F8-9CFA-4EC0-B728-D17CE7CB0D61Q34576070-BC91ABA4-E265-4262-BB25-78C83D1BFE3AQ34864372-977BAC75-5646-4AE8-8F93-FE7F2A205BDFQ36384570-78BE4802-2048-4965-87AB-EC58AECC43A3Q36713853-CD8DBCC6-E78F-4C22-99A4-1F4D0E54C87EQ37166082-A7D39F93-FFDD-4A79-8DD9-B712439A24AAQ37299632-6C28B1A2-2CF9-4CB5-AC99-FF21937655C6Q37306830-FCC5AA28-F43D-4C0B-85AB-119C739CC5C3Q37343949-47DCC49D-66B1-434D-9566-5DDDF5339B6FQ37688808-EEAC1B32-D1C6-4741-9424-084359420F99Q39332938-B466D5FC-05DC-4B5B-A323-9CB7811E8249Q48132331-F17B7D84-9CDA-44EB-8F38-37C931218EECQ51795712-C296946A-886E-4B30-A5D7-1E1D744D9462
P2860
RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
RING-dependent tumor suppressi ...... hereditary kidney cancer gene
@ast
RING-dependent tumor suppressi ...... hereditary kidney cancer gene
@en
RING-dependent tumor suppressi ...... hereditary kidney cancer gene
@en-gb
RING-dependent tumor suppressi ...... hereditary kidney cancer gene
@nl
type
label
RING-dependent tumor suppressi ...... hereditary kidney cancer gene
@ast
RING-dependent tumor suppressi ...... hereditary kidney cancer gene
@en
RING-dependent tumor suppressi ...... hereditary kidney cancer gene
@en-gb
RING-dependent tumor suppressi ...... hereditary kidney cancer gene
@nl
prefLabel
RING-dependent tumor suppressi ...... hereditary kidney cancer gene
@ast
RING-dependent tumor suppressi ...... hereditary kidney cancer gene
@en
RING-dependent tumor suppressi ...... hereditary kidney cancer gene
@en-gb
RING-dependent tumor suppressi ...... hereditary kidney cancer gene
@nl
P2093
P2860
P356
P1433
P1476
RING-dependent tumor suppressi ...... hereditary kidney cancer gene
@en
P2093
A Brauweiler
A M Weissman
H A Drabkin
K L Lorick
R M Gemmill
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210017
P407
P577
2007-04-05T00:00:00Z
P5875
P6179
1015478689