IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
about
In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human isletsZinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrestIdentification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcriptionInsulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitroCooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouseIdentification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional networkInsm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cellsStructure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation.Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells.Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development.Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation.Genomewide expression analysis in zebrafish mind bomb alleles with pancreas defects of different severity identifies putative Notch responsive genesCharacterization of the proneural gene regulatory network during mouse telencephalon developmentExpression of zebrafish pax6b in pancreas is regulated by two enhancers containing highly conserved cis-elements bound by PDX1, PBX and PREP factorsTargeted deficiency of the transcriptional activator Hnf1alpha alters subnuclear positioning of its genomic targetsNeurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas.INSM1 promoter-driven adenoviral herpes simplex virus thymidine kinase cancer gene therapy for the treatment of primitive neuroectodermal tumorsRecent progress on normal and malignant pancreatic stem/progenitor cell research: therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer.Insulinoma-associated antigen-1 zinc-finger transcription factor promotes pancreatic duct cell trans-differentiation.Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic miceXenopus pancreas developmentXenopus insm1 is essential for gastrointestinal and pancreatic endocrine cell development.Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming.Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell developmentRegulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreasA mouse model for monitoring islet cell genesis and developing therapies for diabetesOVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas.Expression of insulinoma-associated 2 (INSM2) in pancreatic islet cells is regulated by the transcription factors Ngn3 and NeuroD1Streptozotocin-induced expression of Ngn3 and Pax4 in neonatal rat pancreatic α-cells.Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expression and localization of the immediate early protein ICP0.Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation.Neonatal diabetes and congenital malabsorptive diarrhea attributable to a novel mutation in the human neurogenin-3 gene coding sequenceNew insights into endocrine pancreatic development: the role of environmental factors.G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesisFunctional role of an islet transcription factor, INSM1/IA-1, on pancreatic acinar cell trans-differentiationL-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway.Neurogenin 3 recruits CBP co-activator to facilitate histone H3/H4 acetylation in the target gene INSM1.The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas.
P2860
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P2860
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
description
2006 nî lūn-bûn
@nan
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas
@nl
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
@ast
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
@en
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
@en-gb
type
label
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas
@nl
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
@ast
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
@en
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
@en-gb
prefLabel
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas
@nl
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
@ast
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
@en
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
@en-gb
P2093
P2860
P50
P921
P356
P1433
P1476
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
@en
P2093
Ahmed Mansouri
Daniel Pipeleers
Finn C Nielsen
Georg Mellitzer
Harry Heimberg
Jacqueline Lee
Mark Van De Casteele
Michael Lan
Nathalie Lenne-Samuel
Reini F Luco
P2860
P304
P356
10.1038/SJ.EMBOJ.7601011
P407
P577
2006-03-02T00:00:00Z