Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR - Wikidata - awgldk - TriplyDB

Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR

Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR

http://www.wikidata.org/entity/Q24306915

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Cell-based small-molecule compound screen identifies fenretinide as potential therapeutic for translocation-positive rhabdomyosarcoma Verification of genes differentially expressed in neuroblastoma tumours: a study of potential tumour suppressor genes Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas.Carnitine palmitoyltransferase 1A (CPT1A): a transcriptional target of PAX3-FKHR and mediates PAX3-FKHR-dependent motility in alveolar rhabdomyosarcoma cells The PAX3-FOXO1 fusion protein present in rhabdomyosarcoma interferes with normal FOXO activity and the TGF-β pathway.Pax genes in embryogenesis and oncogenesis.Alveolar rhabdomyosarcoma - The molecular drivers of PAX3/7-FOXO1-induced tumorigenesis FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma.Comparative transcriptomic analysis reveals the oncogenic fusion protein PAX3-FOXO1 globally alters mRNA and miRNA to enhance myoblast invasion.The RhoE/ROCK/ARHGAP25 signaling pathway controls cell invasion by inhibition of Rac activity.Pigmentation PAX-ways: the role of Pax3 in melanogenesis, melanocyte stem cell maintenance, and disease Diagnostic and prognostic sarcoma signatures.PAX3-FKHR sensitizes human alveolar rhabdomyosarcoma cells to camptothecin-mediated growth inhibition and apoptosis.Small molecule inhibition of PAX3-FOXO1 through AKT activation suppresses malignant phenotypes of alveolar rhabdomyosarcoma PAX3-FKHR regulates the expression of pleiotrophin to mediate motility in alveolar rhabdomyosarcoma cells.Helicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma.Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression.High expression of the PAX3-FKHR oncoprotein is required to promote tumorigenesis of human myoblasts Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma.Gene expression profiling for the investigation of soft tissue sarcoma pathogenesis and the identification of diagnostic, prognostic, and predictive biomarkers.Molecular and cellular biology of rhabdomyosarcoma.Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects.Caveolins in rhabdomyosarcoma Rhabdomyosarcomas: an overview on the experimental animal models.A call to ARMS: targeting the PAX3-FOXO1 gene in alveolar rhabdomyosarcoma.Identification of target genes of PAX3-FOXO1 in alveolar rhabdomyosarcoma.PAX3-FOXO1 is essential for tumour initiation and maintenance but not recurrence in a human myoblast model of rhabdomyosarcoma.P/CAF mediates PAX3-FOXO1-dependent oncogenesis in alveolar rhabdomyosarcoma.Molecular diagnostics in the management of rhabdomyosarcoma.p21 Downregulation is an important component of PAX3/FKHR oncogenicity and its reactivation by HDAC inhibitors enhances combination treatment.Pax7-FKHR transcriptional activity is enhanced by transcriptionally repressed MyoD.Lobular carcinoma in situ and invasive lobular breast cancer are characterized by enhanced expression of transcription factor AP-2β.PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma.New approaches for pediatric rhabdomyosarcoma drug discovery: targeting combinatorial signaling.PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis.PPP2R1A regulated by PAX3/FOXO1 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma.

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Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR

http://www.wikidata.org/entity/Q24306915

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2007 nî lūn-bûn

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2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2007 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年学术文章

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2007年学术文章

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Comparative expression profili ...... survival function of PAX3/FKHR

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Comparative expression profili ...... survival function of PAX3/FKHR

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Comparative expression profili ...... survival function of PAX3/FKHR

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Comparative expression profili ...... survival function of PAX3/FKHR

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Comparative expression profili ...... survival function of PAX3/FKHR

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Comparative expression profili ...... survival function of PAX3/FKHR

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Comparative expression profili ...... survival function of PAX3/FKHR

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Comparative expression profili ...... survival function of PAX3/FKHR

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Comparative expression profili ...... survival function of PAX3/FKHR

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Comparative expression profili ...... survival function of PAX3/FKHR

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Comparative expression profili ...... survival function of PAX3/FKHR

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F K Niggli

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M Ebauer

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M Wachtel

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P2860

The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3

Terminal renal failure in mice lacking transcription factor AP-2 beta

PAX3-FKHR induces morphological change and enhances cellular proliferation and invasion in rhabdomyosarcoma

The oncogenic potential of the Pax3-FKHR fusion protein requires the Pax3 homeodomain recognition helix but not the Pax3 paired-box DNA binding domain.

Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor.

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10.1038/SJ.ONC.1210525

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51

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26

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1040506288

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17525748

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negative regulation of apoptotic process

Transcription factor AP-2 beta

Transcription factor AP-2 beta