Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas.
about
Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cellsPreclinical Childhood Sarcoma Models: Drug Efficacy Biomarker Identification and ValidationUsing large-scale genomics data to identify driver mutations in lung cancer: methods and challengesCell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcomaCross Talk between Wnt/β-Catenin and CIP2A/Plk1 Signaling in Prostate Cancer: Promising Therapeutic ImplicationsHuman rhabdomyosarcoma cell lines for rhabdomyosarcoma research: utility and pitfalls.RNAi phenotype profiling of kinases identifies potential therapeutic targets in Ewing's sarcoma.Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells.Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cellsInitial testing (stage 1) of the Polo-like kinase inhibitor volasertib (BI 6727), by the Pediatric Preclinical Testing Program.Targeting wild-type and mutationally activated FGFR4 in rhabdomyosarcoma with the inhibitor ponatinib (AP24534).PLK1 is a critical determinant of tumor cell sensitivity to CPT11 and its inhibition enhances the drug antitumor efficacy in squamous cell carcinoma models sensitive and resistant to camptothecins.Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine GliomaIdentification of synthetic lethality of PLK1 inhibition and microtubule-destabilizing drugs.Identification of key genes in glioblastoma-associated stromal cells using bioinformatics analysis.The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models.Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition.Antitumoral effect of PLK-1-inhibitor BI2536 in combination with cisplatin and docetaxel in squamous cell carcinoma cell lines of the head and neck.The importance of being dead: cell death mechanisms assessment in anti-sarcoma therapy.Synergistic induction of apoptosis by a polo-like kinase 1 inhibitor and microtubule-interfering drugs in Ewing sarcoma cells.Targeting polo-like kinase 1 by NMS-P937 in osteosarcoma cell lines inhibits tumor cell growth and partially overcomes drug resistance.Polo-like kinase 1 inhibition causes decreased proliferation by cell cycle arrest, leading to cell death in glioblastoma.Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide.Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice.Eribulin alone or in combination with the PLK1 inhibitor BI 6727 triggers intrinsic apoptosis in Ewing sarcoma cell lines.Systematic analysis of RNAi reports identifies dismal commonality at gene-level and reveals an unprecedented enrichment in pooled shRNA screens.Targeting Polo-like kinase 1 in SMARCB1 deleted atypical teratoid rhabdoid tumor.New approaches for pediatric rhabdomyosarcoma drug discovery: targeting combinatorial signaling.Using a rhabdomyosarcoma patient-derived xenograft to examine precision medicine approaches and model acquired resistance.Methods and approaches to disease mechanisms using systems kinomics.
P2860
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P2860
Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Small interfering RNA library ...... f pediatric rhabdomyosarcomas.
@ast
Small interfering RNA library ...... f pediatric rhabdomyosarcomas.
@en
Small interfering RNA library ...... f pediatric rhabdomyosarcomas.
@nl
type
label
Small interfering RNA library ...... f pediatric rhabdomyosarcomas.
@ast
Small interfering RNA library ...... f pediatric rhabdomyosarcomas.
@en
Small interfering RNA library ...... f pediatric rhabdomyosarcomas.
@nl
prefLabel
Small interfering RNA library ...... f pediatric rhabdomyosarcomas.
@ast
Small interfering RNA library ...... f pediatric rhabdomyosarcomas.
@en
Small interfering RNA library ...... f pediatric rhabdomyosarcomas.
@nl
P2093
P2860
P4510
P1476
Small interfering RNA library ...... f pediatric rhabdomyosarcomas.
@en
P2093
Abbas Fotovati
Alastair Davies
Daniel Wai
Elizabeth R Lawlor
Samah Abu-Ali
Sandra E Dunn
Timothy J Triche
P2860
P304
P356
10.1158/1535-7163.MCT-09-0365
P577
2009-11-03T00:00:00Z