Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt
about
PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in miceViral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?Turning off AKT: PHLPP as a drug targetScribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary glandThe Mammalian Blood-Testis Barrier: Its Biology and RegulationWD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1)Suppression of survival signalling pathways by the phosphatase PHLPPDiscovery and confirmation of ligand binding specificities of the Schistosoma japonicum polarity protein ScribbleZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarityThe cell polarity protein Scrib functions as a tumor suppressor in liver cancer.Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancerA novel interaction between hScrib and PP1γ downregulates ERK signaling and suppresses oncogene-induced cell transformation.Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling.Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug ResistanceDiacylglycerol kinase δ modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2)FANCI is a negative regulator of Akt activation.Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1.The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.PHLPP phosphatases as a therapeutic target in insulin resistance-related diseases.The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer.PHLPP regulates hexokinase 2-dependent glucose metabolism in colon cancer cells.A βPIX-PAK2 complex confers protection against Scrib-dependent and cadherin-mediated apoptosis.Antibody crossreactivity between the tumour suppressor PHLPP1 and the proto-oncogene β-catenin.A novel immunomodulatory function of PHLPP1: inhibition of iNOS via attenuation of STAT1 ser727 phosphorylation in mouse macrophages.Pleckstrin Homology (PH) Domain Leucine-rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C.Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.
P2860
Q24337364-F9C729AB-6A02-451D-AE21-B7A619D05D15Q26770053-354ED35C-0766-4138-8758-C1DAAA714AD7Q27014094-F9A5568D-4F38-4973-AF67-A3DA03E23BEBQ27315980-FED353B7-364B-463B-8D97-582FB00C14F5Q28088573-FD6E25C5-2439-4FDF-A7A4-6543F91F7AF6Q28116016-D8521ADC-20AE-48DF-BE02-324E56AE78B9Q28388451-83964B17-CA2F-46CF-86E3-9D440AAD9C99Q28538306-6659D7D8-04A1-4AB1-B990-6D9470BBB3C3Q28829707-BF3D98C8-AA3D-4CE7-9579-7BA11DCE41C7Q33688728-EE39D031-05C9-4338-83D5-146E99616B5CQ33896844-A7322C63-8260-4F01-8E6E-07565CD1FFE7Q34566263-61629CCD-248D-4E3A-90AF-8C7B2B92E986Q35763264-1873E7DF-8E9A-4A3C-A15A-023FBAD86B75Q36283583-78225697-D9E9-4B89-89AE-5886D0089185Q36419257-DBB6857B-E953-41B0-8D8C-266D7D5B7E50Q36543648-753EFAFE-CDF7-48FE-B5DC-F0EAEEB2240CQ36957010-CAAA01B7-C868-4992-AFDD-6654AA05022AQ37542907-8F3C88C8-A5A3-4870-A970-68B639529329Q38038640-3E535E9F-3DFF-42C9-AEE0-EF8422BDBEEBQ38664551-6C86BB91-D2C9-4C3E-9E3F-F46EB5FF9B36Q39385204-01B7A0BD-274B-4843-87B4-F88D255EAA39Q41876633-63317CCE-0C77-4ACC-9DF3-4F8356FAA3A3Q42426815-BC7E4CAF-9E89-49FD-83A7-1FDAD37BB1C6Q42533182-8DA53230-294D-4B56-905C-9E5C136FAF56Q44856542-DF4F18F4-2704-4459-AF48-3938D14AB185Q46874998-57D29E0E-92F0-49ED-9F20-45D4332FD949Q47215536-7DCB5EA2-DB5F-4B8B-8C61-815F7818DAC4
P2860
Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Scribble-mediated membrane tar ...... its negative regulation of Akt
@ast
Scribble-mediated membrane tar ...... its negative regulation of Akt
@en
Scribble-mediated membrane tar ...... its negative regulation of Akt
@en-gb
Scribble-mediated membrane tar ...... its negative regulation of Akt
@nl
type
label
Scribble-mediated membrane tar ...... its negative regulation of Akt
@ast
Scribble-mediated membrane tar ...... its negative regulation of Akt
@en
Scribble-mediated membrane tar ...... its negative regulation of Akt
@en-gb
Scribble-mediated membrane tar ...... its negative regulation of Akt
@nl
prefLabel
Scribble-mediated membrane tar ...... its negative regulation of Akt
@ast
Scribble-mediated membrane tar ...... its negative regulation of Akt
@en
Scribble-mediated membrane tar ...... its negative regulation of Akt
@en-gb
Scribble-mediated membrane tar ...... its negative regulation of Akt
@nl
P2093
P2860
P3181
P356
P1433
P1476
Scribble-mediated membrane tar ...... its negative regulation of Akt
@en
P2093
Haihua Yang
Jianyu Liu
Micheal D Schmidt
Tianyan Gao
P2860
P304
P3181
P356
10.1038/EMBOR.2011.106
P407
P577
2011-08-01T00:00:00Z