PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
about
PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growthThe phosphatase PHLPP controls the cellular levels of protein kinase CScribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Aktc-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanismsInteractome of the negative regulator of nuclear import BRCA1-binding protein 2PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in micePurinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatasesPHLiPPing the switch on Akt and protein kinase C signalingLoss of PHLPP expression in colon cancer: role in proliferation and tumorigenesisUbiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 responseAKT/PKB signaling: navigating downstreamDepletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoformsPI3K-PKB/Akt pathwayNuclear PI3K signaling in cell growth and tumorigenesisCellular prostatic acid phosphatase, a PTEN-functional homologue in prostate epithelia, functions as a prostate-specific tumor suppressorRegulation of mTORC1 by PI3K signalingTurning off AKT: PHLPP as a drug targetMetabolic benefits of resistance training and fast glycolytic skeletal muscle.Maximising the potential of AKT inhibitors as anti-cancer treatmentsPTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastomaWD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1)Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatocellular toxicityBSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiationSuppression of survival signalling pathways by the phosphatase PHLPPThe pursuit of oncotargets through understanding defective cell regulationFKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancerProtein phosphatase PHLPP1 controls the light-induced resetting of the circadian clockSerine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPLPHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampusKCTD20, a relative of BTBD10, is a positive regulator of AktCutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cellsN-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate CancerRegulation of PI3K effector signalling in cancer by the phosphoinositide phosphatasesEvolutionary analysis of PHLPP1 gene in humans and non-human primates.Dormancy of cancer cells with suppression of AKT activity contributes to survival in chronic hypoxia.Protein Ser/Thr phosphatases--the ugly ducklings of cell signalling.The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migrationSCOP/PHLPP1β mediates circadian regulation of long-term recognition memory.CSTP1, a novel protein phosphatase, blocks cell cycle, promotes cell apoptosis, and suppresses tumor growth of bladder cancer by directly dephosphorylating Akt at Ser473 site.Low expression of PHLPP1 in sacral chordoma and its association with poor prognosis.
P2860
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P2860
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
PHLPP and a second isoform, PH ...... gulating distinct Akt isoforms
@ast
PHLPP and a second isoform, PH ...... gulating distinct Akt isoforms
@en
PHLPP and a second isoform, PH ...... gulating distinct Akt isoforms
@en-gb
PHLPP and a second isoform, PH ...... gulating distinct Akt isoforms
@nl
type
label
PHLPP and a second isoform, PH ...... gulating distinct Akt isoforms
@ast
PHLPP and a second isoform, PH ...... gulating distinct Akt isoforms
@en
PHLPP and a second isoform, PH ...... gulating distinct Akt isoforms
@en-gb
PHLPP and a second isoform, PH ...... gulating distinct Akt isoforms
@nl
prefLabel
PHLPP and a second isoform, PH ...... gulating distinct Akt isoforms
@ast
PHLPP and a second isoform, PH ...... gulating distinct Akt isoforms
@en
PHLPP and a second isoform, PH ...... gulating distinct Akt isoforms
@en-gb
PHLPP and a second isoform, PH ...... gulating distinct Akt isoforms
@nl
P2093
P3181
P1433
P1476
PHLPP and a second isoform, PH ...... gulating distinct Akt isoforms
@en
P2093
Emma Sierecki
John Brognard
Tianyan Gao
P304
P3181
P356
10.1016/J.MOLCEL.2007.02.017
P407
P577
2007-03-23T00:00:00Z