LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
about
Role of Microenvironment in Resistance to Therapy in AMLLRRK2 at the interface of autophagosomes, endosomes and lysosomesmTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1Dynasore blocks evoked release while augmenting spontaneous synaptic transmission from primary visceral afferents.A time course of orchestrated endophilin action in sensing, bending, and stabilizing curved membranes.Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S MutationParkin Deficiency Reduces Hippocampal Glutamatergic Neurotransmission by Impairing AMPA Receptor Endocytosis.The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.Effects of LRRK2 Inhibitors on Nigrostriatal Dopaminergic NeurotransmissionEndogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons.Cellular processes associated with LRRK2 function and dysfunctionLRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway.Leucine-rich repeat kinase 2 and Parkinson's disease.Defects in trafficking bridge Parkinson's disease pathology and genetics.Deciphering the BAR code of membrane modulators.Autophagy in the presynaptic compartment in health and disease.Regulation of LRRK2 promoter activity and gene expression by Sp1.Parkinson disease-associated LRRK2 G2019S transgene disrupts marrow myelopoiesis and peripheral Th17 response.Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System.LRRK2 Regulates Voltage-Gated Calcium Channel FunctionLRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.Synapses in neurodegenerative diseases.Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons.Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson's Disease.Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons.Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila.A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci.DJ-1 deficiency impairs synaptic vesicle endocytosis and reavailability at nerve terminals.Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.Optogenetic and chemogenetic techniques for neurogastroenterology.LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
P2860
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P2860
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
description
2015 nî lūn-bûn
@nan
2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
@ast
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
@en
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
@en-gb
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
@nl
type
label
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
@ast
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
@en
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
@en-gb
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
@nl
prefLabel
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
@ast
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
@en
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
@en-gb
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
@nl
P2093
P50
P3181
P356
P1476
LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
@en
P2093
Amaia M Arranz
Diederik Moechars
Guy Daneels
Hamdy Shaban
Kristof Van Kolen
Lore Delbroek
Marco R Guimarães
Pieter Baatsen
Samer Matta
Sara Calafate
P304
P3181
P356
10.1242/JCS.158196
P407
P577
2015-02-01T00:00:00Z