Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair
about
Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PKBase Excision Repair, a Pathway Regulated by Posttranslational ModificationsATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancersXRCC1 Arg399Gln polymorphism confers risk of breast cancer in American population: a meta-analysis of 10846 cases and 11723 controlsThe Effect of MicroRNA-124 Overexpression on Anti-Tumor Drug SensitivityX-ray repair cross complementing protein 1 in base excision repair.X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and risk of childhood acute lymphoblastic leukemia: a meta-analysis.A network of conserved damage survival pathways revealed by a genomic RNAi screen.DNA breaks and chromosomal aberrations arise when replication meets base excision repair.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.Accumulation of true single strand breaks and AP sites in base excision repair deficient cellsPoly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles.Activation of checkpoint kinase 2 is critical for herpes simplex virus type 1 replication in corneal epitheliumATM prevents DSB formation by coordinating SSB repair and cell cycle progression.Interaction with OGG1 is required for efficient recruitment of XRCC1 to base excision repair and maintenance of genetic stability after exposure to oxidative stressNew paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins.The R280H X-ray cross-complementing 1 germline variant induces genomic instability and cellular transformationN-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents.Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activityDistinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair.Quantitative assessment of the associations between XRCC1 polymorphisms and bladder cancer riskMind the gap: keeping UV lesions in check.Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress.No association between XRCC1 genetic polymorphisms and differentiated thyroid carcinoma risk: a meta-analysis.p38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damageInitiation of the ATM-Chk2 DNA damage response through the base excision repair pathway.FGFR2 regulates Mre11 expression and double-strand break repair via the MEK-ERK-POU1F1 pathway in breast tumorigenesis.The prion protein is critical for DNA repair and cell survival after genotoxic stress.DNA repair and mutations during quiescence in yeast.Functional activation of ATM by the prostate cancer suppressor NKX3.1.XRCC1 interaction with the REV1 C-terminal domain suggests a role in post replication repairDNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrityBiomarkers for genome instability in some genetic disorders: a pilot study.Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiencyTdp1 protects against oxidative DNA damage in non-dividing fission yeast.Promotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli.ATM-dependent pathways of chromatin remodelling and oxidative DNA damage responses.
P2860
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P2860
Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Chk2-dependent phosphorylation ...... promotes base excision repair
@ast
Chk2-dependent phosphorylation ...... promotes base excision repair
@en
Chk2-dependent phosphorylation ...... promotes base excision repair
@en-gb
Chk2-dependent phosphorylation ...... promotes base excision repair
@nl
type
label
Chk2-dependent phosphorylation ...... promotes base excision repair
@ast
Chk2-dependent phosphorylation ...... promotes base excision repair
@en
Chk2-dependent phosphorylation ...... promotes base excision repair
@en-gb
Chk2-dependent phosphorylation ...... promotes base excision repair
@nl
prefLabel
Chk2-dependent phosphorylation ...... promotes base excision repair
@ast
Chk2-dependent phosphorylation ...... promotes base excision repair
@en
Chk2-dependent phosphorylation ...... promotes base excision repair
@en-gb
Chk2-dependent phosphorylation ...... promotes base excision repair
@nl
P2093
P2860
P356
P1433
P1476
Chk2-dependent phosphorylation ...... promotes base excision repair
@en
P2093
Fen-Hwa Wong
Hui-Chun Wang
Sheau-Yann Shieh
Shian-ling Ding
Wen-Cheng Chou
P2860
P304
P356
10.1038/EMBOJ.2008.229
P407
P577
2008-12-03T00:00:00Z