An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita
about
Evolution of a novel subfamily of nuclear receptors with members that each contain two DNA binding domainsOrphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNAUp-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.NELF is a nuclear protein involved in hypothalamic GnRH neuronal migrationRepressors of androgen and progesterone receptor actionSevere combined adrenal and gonadal deficiency caused by novel mutations in the cholesterol side chain cleavage enzyme, P450sccDNA binding and transcriptional repression by DAX-1 blocks steroidogenesisMutations and phenotype in isolated glycerol kinase deficiencyDAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expressionLXXLL motifs and AF-2 domain mediate SHP (NR0B2) homodimerization and DAX1 (NR0B1)-DAX1A heterodimerizationThe orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repressionThe molecular biology, biochemistry, and physiology of human steroidogenesis and its disordersA novel mutation in DAX1 causes delayed-onset adrenal insufficiency and incomplete hypogonadotropic hypogonadismMale sex determination: insights into molecular mechanismsFeminizing chicks: a model for avian sex determination based on titration of Hint enzyme activity and the predicted structure of an Asw-Hint heterodimerSF-1 a key player in the development and differentiation of steroidogenic tissuesAn autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRgammaEvolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic GenesDAX-1 (NR0B1) and steroidogenic factor-1 (SF-1, NR5A1) in human diseaseThe structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenitaHuman Y chromosome, sex determination, and spermatogenesis- a feminist viewSmall heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivationPrimate DAX1, SRY, and SOX9: evolutionary stratification of sex-determination pathway.Dax1 antagonizes Sry action in mammalian sex determinationFollistatin operates downstream of Wnt4 in mammalian ovary organogenesisPPAR-gamma coactivator-1alpha regulates progesterone production in ovarian granulosa cells with SF-1 and LRH-1Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiencyIsolation and characterization of a MAGE gene family in the Xp21.3 regionSex determination in the chicken embryo.Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta.Characterization of the Xp21-23 region in the wood lemming, a region involved in XY sex reversal.Advances in the molecular genetics of hypogonadotropic hypogonadism.Cloning, expression analysis and chromosomal localization of the human nuclear receptor gene GCNF.Specificity of DNA-binding by the FAX-1 and NHR-67 nuclear receptors of Caenorhabditis elegans is partially mediated via a subclass-specific P-box residue.Human sex determination.Mammalian sex determination: joining pieces of the genetic puzzle.Transcriptional regulation by DNA structural transitions and single-stranded DNA-binding proteins.Down syndrome in association with features of the androgen insensitivity syndrome.
P2860
331405af3d0b398571490185f46f3a7dac11d87f3ef400fa3f2652cc8f80015fa3e37959d4e8b17c717c467e37c5aeec9462ec3cf182bafb15946d368a83878dc164f41d8e0fedfd3670ab05c3c33ab2a0c196cdca9a30208bdce956750faf2a1d99392ab1c3c7e4ed796c0f2dbe6a8c4c191972491a4ed6b7056900374aa2a5ba8b6804b4b7a936b9afa6dfc28bdb51ed3e155e4b1923de7305d735905259d1cc216d480392618b89a6bb96fba78612e1ad8609d56b2f3569feecd63d78f00ce1bd8c3aab9fcbe6
P248
Q21283917-F5CA9788-3B81-45A7-BA33-4A6544D9A8F9Q22254231-9ACCA802-C3CA-455C-AA75-ECB0A6A30C93Q24291076-A40DF675-FDF6-4CD7-92CC-9D85DC235C3CQ24292996-4B8362AE-3AD2-41A2-9964-87ACD1B3880EQ24303288-44D1E4DA-1C8C-411D-8061-0B61B9EAABB0Q24305963-27CA79D1-99FE-4FBC-AB77-31B730F3DCA9Q24310202-071D64A5-E8CF-4119-9A0A-598912BA185FQ24317063-2BA0F127-34C0-4E10-80C1-B2F9B855664EQ24320012-CA98008E-9D4B-4BCE-AE0D-3AC09BFD0AE5Q24336988-6E3940BA-EC4E-4C85-ACB6-C5B91CF8DF01Q24554362-39D9F5E0-8E9F-4E83-822D-46C2107B7033Q24613957-A25E9E72-DF78-4ABA-BF05-E60C66C585BFQ24621014-3EB8425B-EB56-4B0B-A371-E8F163287859Q24633383-89D4E2A6-79CE-4C4D-A023-9925ACF7418FQ24791300-928D04FC-051C-4081-9EBC-2CD8A315DE88Q24805943-80957361-3846-476E-BA55-01FDF9B589FDQ24814920-A28C8527-012D-46DB-99FC-EB7A4B8375C9Q24815571-FDA36FA6-970B-4A0F-A120-FEED3FD2D68EQ26749628-38806C26-BE63-43D3-AC58-21CB6984D6A3Q26798022-2ECC17DB-F827-4B69-A8BF-FC43E7DB084AQ27652923-981CAA80-DA3F-49F8-A304-DECF5ABCE421Q28138285-86725E31-EDF3-4107-AE8F-A753C2035B68Q28144290-6A808F29-9C0D-4105-9A76-28B90BBEC614Q28204021-11F39D0D-0917-46E4-8FDF-83125C20C2AEQ28345004-C6F73123-3D83-438F-B3F2-C36184CFBFE3Q28508912-42A8415B-D715-49AC-97A3-2E82037EA727Q28510588-AFB0187F-4E72-45FC-AAAB-EEFF4449C243Q28584186-EB7E101C-3E58-48FC-9EC8-C671334652E5Q28594428-993CC818-3760-415C-AB91-2EF38E7A30FBQ30418464-8D968DDC-42BC-4020-9950-32EE1A1F181BQ30780680-302823E8-2BFD-48BA-9E79-1D983568CEA1Q30815190-0B82356A-2E87-4AAE-A5A3-F25AA1CAA603Q31032721-C3D1D33B-3CF1-45F0-A234-C52DB1E710DAQ32061114-75611FCA-9845-467B-ADB3-430D50EA2C30Q32069085-4B1B443A-CD23-423B-8E12-7BD76EE2B5D4Q33313520-A4A5D56D-73B3-4AF4-B46B-E05B98188CC0Q33368735-8ADF35F1-B862-4D2F-BE5B-C8B710D107BBQ33368887-E7054630-BFFE-4C18-91AA-10089EFB64EFQ33671291-AFDFB107-7F79-47EC-8BED-C2860C049BF9Q33677538-438D20A3-ABFE-44A6-ABBF-190F0C157C6D
P2860
An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita
description
1994 nî lūn-bûn
@nan
1994 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
An unusual member of the nucle ...... d adrenal hypoplasia congenita
@ast
An unusual member of the nucle ...... d adrenal hypoplasia congenita
@en
An unusual member of the nucle ...... d adrenal hypoplasia congenita
@en-gb
An unusual member of the nucle ...... d adrenal hypoplasia congenita
@nl
type
label
An unusual member of the nucle ...... d adrenal hypoplasia congenita
@ast
An unusual member of the nucle ...... d adrenal hypoplasia congenita
@en
An unusual member of the nucle ...... d adrenal hypoplasia congenita
@en-gb
An unusual member of the nucle ...... d adrenal hypoplasia congenita
@nl
prefLabel
An unusual member of the nucle ...... d adrenal hypoplasia congenita
@ast
An unusual member of the nucle ...... d adrenal hypoplasia congenita
@en
An unusual member of the nucle ...... d adrenal hypoplasia congenita
@en-gb
An unusual member of the nucle ...... d adrenal hypoplasia congenita
@nl
P2093
P921
P3181
P356
P1433
P1476
An unusual member of the nucle ...... d adrenal hypoplasia congenita
@en
P2093
A P Walker
E R McCabe
F Muscatelli
P2888
P304
P3181
P356
10.1038/372635A0
P407
P577
1994-12-15T00:00:00Z
P5875
P6179
1027354836