Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins - Wikidata - awgldk - TriplyDB

Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins

Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins

http://www.wikidata.org/entity/Q24310801

about

Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen Growth factor priming differentially modulates components of the extracellular matrix proteome in chondrocytes and synovium-derived stem cells D469del-COMP retention in chondrocytes stimulates caspase-independent necroptosis Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation Antioxidant and anti-inflammatory agents mitigate pathology in a mouse model of pseudoachondroplasia The evolution of thrombospondins and their ligand-binding activities Molecular basis of antiangiogenic thrombospondin-1 type 1 repeat domain interactions with CD36 Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis.Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growth.Cartilage oligomeric matrix protein (COMP) forms part of the connective tissue of normal human hair follicles.Granulin-epithelin precursor binds directly to ADAMTS-7 and ADAMTS-12 and inhibits their degradation of cartilage oligomeric matrix protein ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis.Pseudoachondroplasia/COMP - translating from the bench to the bedside.Elevated Levels of Cartilage Oligomeric Matrix Protein during In Vitro Cartilage Matrix Generation Decrease Collagen Fibril Diameter.Mild myopathy is associated with COMP but not MATN3 mutations in mouse models of genetic skeletal diseases.Cartilage oligomeric matrix protein in idiopathic pulmonary fibrosis.Abnormal chondrocyte apoptosis in the cartilage growth plate is influenced by genetic background and deletion of CHOP in a targeted mouse model of pseudoachondroplasia Cartilage oligomeric matrix protein promotes cell attachment via two independent mechanisms involving CD47 and alphaVbeta3 integrin.The thrombospondins.Revisiting the matricellular concept.Matricellular proteins in cardiac adaptation and disease.Enhanced activity of transforming growth factor β1 (TGF-β1) bound to cartilage oligomeric matrix protein.A 3D Porous Gelatin-Alginate-Based-IPN Acts as an Efficient Promoter of Chondrogenesis from Human Adipose-Derived Stem Cells.Deficiency of Thrombospondin-4 in Mice Does Not Affect Skeletal Growth or Bone Mass Acquisition, but Causes a Transient Reduction of Articular Cartilage Thickness Cartilage oligomeric matrix protein enhances matrix assembly during chondrogenesis of human mesenchymal stem cells.A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia.Proteomic analysis of Col11a1-associated protein complexes.Integrins and chondrocyte-matrix interactions in articular cartilage CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes Maximizing phenotype constraint and extracellular matrix production in primary human chondrocytes using arginine-glycine-aspartate concentration gradient hydrogels Thrombospondins in cancer.Ribozyme-mediated reduction of wild-type and mutant cartilage oligomeric matrix protein (COMP) mRNA and protein ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor.

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P2860

Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins

http://www.wikidata.org/entity/Q24310801

description

2005 nî lūn-bûn

@nan

2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2005年の論文

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2005年論文

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2005年論文

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2005年論文

@zh-hk

2005年論文

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2005年論文

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2005年论文

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name

Cartilage oligomeric matrix pr ...... ugh interaction with integrins

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Cartilage oligomeric matrix pr ...... ugh interaction with integrins

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Cartilage oligomeric matrix pr ...... ugh interaction with integrins

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Cartilage oligomeric matrix pr ...... ugh interaction with integrins

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type

label

Cartilage oligomeric matrix pr ...... ugh interaction with integrins

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Cartilage oligomeric matrix pr ...... ugh interaction with integrins

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Cartilage oligomeric matrix pr ...... ugh interaction with integrins

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Cartilage oligomeric matrix pr ...... ugh interaction with integrins

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Cartilage oligomeric matrix pr ...... ugh interaction with integrins

@ast

Cartilage oligomeric matrix pr ...... ugh interaction with integrins

@en

Cartilage oligomeric matrix pr ...... ugh interaction with integrins

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Cartilage oligomeric matrix pr ...... ugh interaction with integrins

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P1433

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P2860

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P1433

Journal of Biological Chemistry

P1476

Cartilage oligomeric matrix pr ...... ugh interaction with integrins

@en

P2093

Ashby O Thomas

http://www.w3.org/2001/XMLSchema#string

Faye Hui Chen

http://www.w3.org/2001/XMLSchema#string

Jack Lawler

http://www.w3.org/2001/XMLSchema#string

Jacqueline T Hecht

http://www.w3.org/2001/XMLSchema#string

Mary B Goldring

http://www.w3.org/2001/XMLSchema#string

P2860

Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes

Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX

Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin

Characterization of human and mouse cartilage oligomeric matrix protein

Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene

Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees

Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen

Characterization of cartilage oligomeric matrix protein (COMP) in human normal and pseudoachondroplasia musculoskeletal tissues

Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia

Mechanotransduction via integrins and interleukinâ 4 results in altered aggrecan and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic, human articular chondrocytes

P304

32655-61

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scholarly article

P356

10.1074/JBC.M504778200

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P407

P433

38

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P478

280

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P577

2005-09-23T00:00:00Z

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16051604

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P921

P932

2896261

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