CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes - Wikidata - awgldk - TriplyDB

CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes

CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes

http://www.wikidata.org/entity/Q36496112

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CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis Roles for CCN2 in normal physiological processes Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signalling CTGF is increased in basal deposits and regulates matrix production through the ERK (p42/p44mapk) MAPK and the p38 MAPK signaling pathways.Prostaglandin E2 regulates the expression of connective tissue growth factor (CTGF/CCN2) in human osteoarthritic chondrocytes via the EP4 receptor Connective tissue growth factor promotes fibrosis downstream of TGFbeta and IL-6 in chronic cardiac allograft rejection.A microarray analysis of full depth knee cartilage of ovariectomized rats.Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin.Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: implication in the pathogenesis of severe bronchopulmonary dysplasia RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism The role of connective tissue growth factor (CTGF/CCN2) in skeletogenesis.Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts.Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity.CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress.Osteogenic differentiation of mesenchymal stem cells promoted by overexpression of connective tissue growth factor.CCN family 2/connective tissue growth factor (CCN2/CTGF) regulates the expression of Vegf through Hif-1alpha expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition.CCN2 suppresses catabolic effects of interleukin-1β through α5β1 and αVβ3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration.Molecular Therapy for Degenerative Disc Disease: Clues from Secretome Analysis of the Notochordal Cell-Rich Nucleus Pulposus.Molecular regulation of CCN2 in the intervertebral disc: lessons learned from other connective tissues The role of the CCN family of proteins in female reproduction.CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP).The pivotal role of CCN2 in mammalian palatogenesis Genome-wide study identifies the regulatory gene networks and signaling pathways from chondrocyte and peripheral blood monocyte of Kashin-Beck disease.CCN3: A novel function in vivo.Conditional overexpression of connective tissue growth factor disrupts postnatal lung development Reduced expression of connective tissue growth factor (CTGF/CCN2) mediates collagen loss in chronologically aged human skin.Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo.CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes.Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis The effects of qindan-capsule-containing serum on the TGF-β1/ERK signaling pathway, matrix metalloproteinase synthesis and cell function in adventitial fibroblasts.A friend in knee: CCN3 may inhibit osteoarthritis progression.Cell Biological Assays for Measuring Chondrogenic Activities of CCN2 Protein.Compressive force-produced CCN2 induces osteocyte apoptosis through ERK1/2 pathway.Connective tissue growth factor contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ Development of Normal and Cleft Palate: A Central Role for Connective Tissue Growth Factor (CTGF)/CCN2

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CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes

http://www.wikidata.org/entity/Q36496112

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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CCN2 (Connective Tissue Growth ...... grin signaling in chondrocytes

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CCN2 (Connective Tissue Growth ...... grin signaling in chondrocytes

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CCN2 (Connective Tissue Growth ...... grin signaling in chondrocytes

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CCN2 (Connective Tissue Growth ...... grin signaling in chondrocytes

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CCN2 (Connective Tissue Growth ...... grin signaling in chondrocytes

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CCN2 (Connective Tissue Growth ...... grin signaling in chondrocytes

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S12079-007-0005-Z

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Journal of Cell Communication and Signaling

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CCN2 (Connective Tissue Growth ...... grin signaling in chondrocytes

@en

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Harumi Kawaki

http://www.w3.org/2001/XMLSchema#string

Karen M Lyons

http://www.w3.org/2001/XMLSchema#string

Masaharu Takigawa

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R Andrea Deyoung

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Ruth M Baxter

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Takashi Nishida

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P2860

CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1

Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer

Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins

Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes

CYR61 (CCN1) is essential for placental development and vascular integrity

Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo

Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo

Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development

Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells.

Integrins: bidirectional, allosteric signaling machines

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s12079-007-0005-z

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10.1007/S12079-007-0005-Z

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1

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5370746

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P698

18481209

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extracellular matrix

connective tissue

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2267656

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