SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
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Sumoylation in Synaptic Function and DysfunctionKv5, Kv6, Kv8, and Kv9 subunits: No simple silent bystandersHyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death.One SUMO is sufficient to silence the dimeric potassium channel K2P1DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals.Oxidation of KCNB1 K(+) channels in central nervous system and beyondNeuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction.SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 cells and human islets.Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels.A SUMO-Phospho tag team for wrestling with potassium channel gating.SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neuronsCardiac function and disease: emerging role of small ubiquitin-related modifier.Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules.SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretionThe C-terminus of neuronal Kv2.1 channels is required for channel localization and targeting but not for NMDA-receptor-mediated regulation of channel functionKCNE Regulation of K(+) Channel Trafficking - a Sisyphean Task?Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cellsSUMOylation of pancreatic glucokinase regulates its cellular stability and activityControl of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion.Sumoylation and regulation of cardiac gene expression.Voltage-gated potassium channels as therapeutic targets.Senp2 expression was induced by chronic glucose stimulation in INS1 cells, and it was required for the associated induction of Ccnd1 and Mafa.Signal integration at the level of ion channel and exocytotic function in pancreatic β-cells.A Role for K2P Channels in the Operation of Somatosensory NociceptorsNovel roles of SUMO in pancreatic β-cells: thinking outside the nucleus.Dynamic of ion channel expression at the plasma membrane of cardiomyocytes.Molecular targets underlying SUMO-mediated neuroprotection in brain ischemia.Sumoylation at the host-pathogen interface.In silico prediction of novel therapeutic targets using gene-disease association data.Pancreatic β-cell prosurvival effects of the incretin hormones involve post-translational modification of Kv2.1 delayed rectifier channels.Kv7 channels in the nucleus accumbens are altered by chronic drinking and are targets for reducing alcohol consumption.SUMOylation of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Increases Surface Expression and the Maximal Conductance of the Hyperpolarization-Activated Current.SUMOylation determines the voltage required to activate cardiac IKs channels.SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans.SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells.Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes.Sialic acids attached to O-glycans modulate voltage-gated potassium channel gating.Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells result in impaired beta cell function.SUMO co-expression modifies KV 11.1 channel activity.
P2860
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P2860
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
@ast
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
@en
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
@en-gb
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
@nl
type
label
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
@ast
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
@en
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
@en-gb
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
@nl
prefLabel
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
@ast
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
@en
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
@en-gb
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
@nl
P2093
P921
P3181
P356
P1476
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
@en
P2093
Jelena Kolic
Paolo Marchi
Simonetta Sipione
Xiao-Qing Dai
P304
P3181
P356
10.1242/JCS.036632
P407
P577
2009-02-17T00:00:00Z