Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation
about
A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 proteinTRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressedSEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide productionMutations in presenilin 2 and its implications in Alzheimer's disease and other dementia-associated disordersPresenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-cateninInteraction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell deathThe mitochondrial serine protease HtrA2/Omi: an overviewFe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor proteinAggresomes: a cellular response to misfolded proteinsMice lacking both presenilin genes exhibit early embryonic patterning defectsPresenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1Identification of genes periodically expressed in the human cell cycle and their expression in tumorsCentrosomal RNA correlates with intron-poor nuclear genes in Spisula oocytesAlzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function.Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.Altered binding of mutated presenilin with cytoskeleton-interacting proteins.Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy ModelsAlzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein.LDLR expression and localization are altered in mouse and human cell culture models of Alzheimer's diseaseAlzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP.The role of cell cycle-mediated events in Alzheimer's disease.APLP2, a member of the Alzheimer precursor protein family, is required for correct genomic segregation in dividing mouse cellsPathological implications of cell cycle re-entry in Alzheimer disease.Presenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cellsPresenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers.Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation.Mitotic spindle defects and chromosome mis-segregation induced by LDL/cholesterol-implications for Niemann-Pick C1, Alzheimer's disease, and atherosclerosis.Neurons bearing presenilins: weapons for defense or suicide?Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells.Is Alzheimer's disease a mitochondrial disorder?Long-term accumulation of amyloid-beta, beta-secretase, presenilin-1, and caspase-3 in damaged axons following brain traumaThe -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain.Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors.RNAi-mediated inhibition of presenilin 2 inhibits glioma cell growth and invasion and is involved in the regulation of Nrg1/ErbB signaling.Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing.Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations.Mitochondrion to endoplasmic reticulum apposition length in zebrafish embryo spinal progenitors is unchanged in response to perturbations associated with Alzheimer's diseaseAlzheimer's disease and HIV associated dementia related genes: I. location and function.The genomically mosaic brain: aneuploidy and more in neural diversity and disease.Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy.
P2860
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P2860
Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation
description
1997 nî lūn-bûn
@nan
1997 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Alzheimer presenilins in the n ...... role in chromosome segregation
@ast
Alzheimer presenilins in the n ...... role in chromosome segregation
@en
Alzheimer presenilins in the n ...... role in chromosome segregation
@en-gb
Alzheimer presenilins in the n ...... role in chromosome segregation
@nl
type
label
Alzheimer presenilins in the n ...... role in chromosome segregation
@ast
Alzheimer presenilins in the n ...... role in chromosome segregation
@en
Alzheimer presenilins in the n ...... role in chromosome segregation
@en-gb
Alzheimer presenilins in the n ...... role in chromosome segregation
@nl
prefLabel
Alzheimer presenilins in the n ...... role in chromosome segregation
@ast
Alzheimer presenilins in the n ...... role in chromosome segregation
@en
Alzheimer presenilins in the n ...... role in chromosome segregation
@en-gb
Alzheimer presenilins in the n ...... role in chromosome segregation
@nl
P2093
P921
P1433
P1476
Alzheimer presenilins in the n ...... role in chromosome segregation
@en
P2093
P304
P356
10.1016/S0092-8674(00)80356-6
P407
P577
1997-09-05T00:00:00Z