Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin
about
Wnt/beta-catenin signaling and small molecule inhibitorsKeeping Wnt signalosome in check by vesicular trafficIntegrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force.The adaptor protein Disabled-2: new insights into platelet biology and integrin signalingEndocytosis and Physiology: Insights from Disabled-2 Deficient MiceIn vivo analysis of formation and endocytosis of the Wnt/β-catenin signaling complex in zebrafish embryosNorrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function.Pathways on demand: automated reconstruction of human signaling networksTyrosine-based signal mediates LRP6 receptor endocytosis and desensitization of Wnt/β-catenin pathway signaling.Hormonal induction and roles of Disabled-2 in lactation and involution.Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer developmentHigh-affinity Dkk1 receptor Kremen1 is internalized by clathrin-mediated endocytosis.Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues.Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively.Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer.Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors.Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/β-catenin signaling.Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes.Enhancement of β-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals.Protein kinase PKN1 represses Wnt/β-catenin signaling in human melanoma cells.The Dickkopf1-cytoskeleton-associated protein 4 axis creates a novel signalling pathway and may represent a molecular target for cancer therapy.p120-catenin in canonical Wnt signaling.Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy.CKAP4 is a Dickkopf1 receptor and is involved in tumor progression.Disabled-2: A modular scaffold protein with multifaceted functions in signaling.MicroRNA-145 regulates disabled-2 and Wnt3a expression in cardiomyocytes under hyperglycaemia.LDL switches the LRP6 internalization route from flotillin dependent to clathrin dependent in hepatic cells.The function of endocytosis in Wnt signaling.TGF-beta signaling in cancer: post-transcriptional regulation of EMT via hnRNP E1.The ubiquitin ligase PDZRN3 is required for vascular morphogenesis through Wnt/planar cell polarity signalling.Altered expression of inflammation-associated genes in oviductal cells following follicular fluid exposure: implications for ovarian carcinogenesis.Deficiency of Dab2 (Disabled Homolog 2) in Myeloid Cells Exacerbates Inflammation in Liver and Atherosclerotic Plaques in LDLR (Low-Density Lipoprotein Receptor)-Null Mice-Brief Report
P2860
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P2860
Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin
description
2012 nî lūn-bûn
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2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Disabled-2 (Dab2) inhibits Wnt ...... ternalization through clathrin
@ast
Disabled-2 (Dab2) inhibits Wnt ...... ternalization through clathrin
@en
Disabled-2 (Dab2) inhibits Wnt ...... ternalization through clathrin
@en-gb
Disabled-2 (Dab2) inhibits Wnt ...... ternalization through clathrin
@nl
type
label
Disabled-2 (Dab2) inhibits Wnt ...... ternalization through clathrin
@ast
Disabled-2 (Dab2) inhibits Wnt ...... ternalization through clathrin
@en
Disabled-2 (Dab2) inhibits Wnt ...... ternalization through clathrin
@en-gb
Disabled-2 (Dab2) inhibits Wnt ...... ternalization through clathrin
@nl
prefLabel
Disabled-2 (Dab2) inhibits Wnt ...... ternalization through clathrin
@ast
Disabled-2 (Dab2) inhibits Wnt ...... ternalization through clathrin
@en
Disabled-2 (Dab2) inhibits Wnt ...... ternalization through clathrin
@en-gb
Disabled-2 (Dab2) inhibits Wnt ...... ternalization through clathrin
@nl
P2093
P2860
P3181
P356
P1433
P1476
Disabled-2 (Dab2) inhibits Wnt ...... ternalization through clathrin
@en
P2093
P2860
P304
P3181
P356
10.1038/EMBOJ.2012.83
P407
P577
2012-05-16T00:00:00Z