The human delta1261 mutation of the HERG potassium channel results in a truncated protein that contains a subunit interaction domain and decreases the channel expression
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A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channelsMolecular pathogenesis of long QT syndrome type 2Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesteraseCarboxy-terminal domain mediates assembly of the voltage-gated rat ether-à-go-go potassium channelIn vivo domain-based functional analysis of the major sporulation sensor kinase, KinA, in Bacillus subtilisThe subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domainsDistal end of carboxyl terminus is not essential for the assembly of rat Eag1 potassium channelsAbsence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methodsInducible polymorphic ventricular tachyarrhythmias in a transgenic mouse model with a long Q-T phenotypePAS domains: internal sensors of oxygen, redox potential, and lightFamilial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current.Electrophysiological study of V535M hERG mutation of LQT2.Dysfunction of delayed rectifier potassium channels in an inherited cardiac arrhythmia.Two distantly positioned PDZ domains mediate multivalent INAD-phospholipase C interactions essential for G protein-coupled signaling.Position of premature termination codons determines susceptibility of hERG mutations to nonsense-mediated mRNA decay in long QT syndromeShaker and ether-à-go-go K+ channel subunits fail to coassemble in Xenopus oocytes.Novel characteristics of a trafficking-defective G572R-hERG channel linked to hereditary long QT syndrome.Genetic disorders of neuromuscular ion channels.hERG1a N-terminal eag domain-containing polypeptides regulate homomeric hERG1b and heteromeric hERG1a/hERG1b channels: a possible mechanism for long QT syndrome.Regulation of K+ channel activities in plants: from physiological to molecular aspects.Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage-gated potassium channel.Regulation of deactivation by an amino terminal domain in human ether-à-go-go-related gene potassium channels.HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometriumNonsense mutations in hERG cause a decrease in mutant mRNA transcripts by nonsense-mediated mRNA decay in human long-QT syndrome.Single nucleotide deletion mutation of KCNH2 gene is responsible for LQT syndrome in a 3-generation Korean family.Novel mechanisms of trafficking defect caused by KCNQ1 mutations found in long QT syndrome.HERG potassium channel regulation by the N-terminal eag domain.Kvbeta2 inhibits the Kvbeta1-mediated inactivation of K+ channels in transfected mammalian cells.Emerging pollutant treatments in wastewater: Cases of antibiotics and hormones.L539 fs/47, a truncated mutation of human ether-a-go-go-related gene (hERG), decreases hERG ion channel currents in HEK 293 cells.A cellular model for long QT syndrome. Trapping of heteromultimeric complexes consisting of truncated Kv1.1 potassium channel polypeptides and native Kv1.4 and Kv1.5 channels in the endoplasmic reticulum.Alternatively spliced forms of the cGMP-gated channel in human keratinocytes.Nonsense-Mediated mRNA Decay of hERG Mutations in Long QT Syndrome.A K+ channel splice variant common in human heart lacks a C-terminal domain required for expression of rapidly activating delayed rectifier current.Characterization of S818L mutation in HERG C-terminus in LQT2. Modification of activation-deactivation gating properties.
P2860
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P2860
The human delta1261 mutation of the HERG potassium channel results in a truncated protein that contains a subunit interaction domain and decreases the channel expression
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
The human delta1261 mutation o ...... creases the channel expression
@ast
The human delta1261 mutation o ...... creases the channel expression
@en
The human delta1261 mutation o ...... creases the channel expression
@en-gb
The human delta1261 mutation o ...... creases the channel expression
@nl
type
label
The human delta1261 mutation o ...... creases the channel expression
@ast
The human delta1261 mutation o ...... creases the channel expression
@en
The human delta1261 mutation o ...... creases the channel expression
@en-gb
The human delta1261 mutation o ...... creases the channel expression
@nl
prefLabel
The human delta1261 mutation o ...... creases the channel expression
@ast
The human delta1261 mutation o ...... creases the channel expression
@en
The human delta1261 mutation o ...... creases the channel expression
@en-gb
The human delta1261 mutation o ...... creases the channel expression
@nl
P2093
P2860
P356
P1476
The human delta1261 mutation o ...... creases the channel expression
@en
P2093
P2860
P356
10.1074/JBC.272.2.705
P407
P577
1997-01-10T00:00:00Z