Regulation of deactivation by an amino terminal domain in human ether-à-go-go-related gene potassium channels.
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Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channelsA recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channelsMechanistic Insight into Human ether-a-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG DomainThe N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel DeactivationStructure of the carboxy-terminal region of a KCNH channelThe S4–S5 Linker Acts as a Signal Integrator for hERG K+ Channel Activation and Deactivation GatingThe structural mechanism of KCNH-channel regulation by the eag domain.Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanismCalmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology DomainRegulation of an ERG K+ current by Src tyrosine kinaseMolecular determinants of interactions between the N-terminal domain and the transmembrane core that modulate hERG K+ channel gating.Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether-à-go-go-Related Gene.Novel characteristics of a misprocessed mutant HERG channel linked to hereditary long QT syndrome.An Interdomain KCNH2 Mutation Produces an Intermediate Long QT SyndromeRole of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels.HERG1 channelopathiesConcerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channelsModulation of the ERG K+ current by the tyrosine phosphatase, SHP-1.Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels.HERG channel (dys)function revealed by dynamic action potential clamp techniqueMutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.The Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels.The schizophrenia-associated Kv11.1-3.1 isoform results in reduced current accumulation during repetitive brief depolarizations.hERG potassium channel gating is mediated by N- and C-terminal region interactionsDemonstration of physical proximity between the N terminus and the S4-S5 linker of the human ether-a-go-go-related gene (hERG) potassium channelEther-à-go-go family voltage-gated K+ channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor.hERG1a N-terminal eag domain-containing polypeptides regulate homomeric hERG1b and heteromeric hERG1a/hERG1b channels: a possible mechanism for long QT syndrome.The Role of the Carboxyl Terminus Helix C-D Linker in Regulating KCNQ3 K+ Current Amplitudes by Controlling Channel TraffickingOpposite Effects of the S4-S5 Linker and PIP(2) on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels.Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channelsBimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate.Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.Fast and slow voltage sensor movements in HERG potassium channels.Negative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes.Dynamic control of deactivation gating by a soluble amino-terminal domain in HERG K(+) channels.The eag domain regulates hERG channel inactivation gating via a direct interaction.Dominant negative consequences of a hERG 1b-specific mutation associated with intrauterine fetal death.Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels.Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domainLQT2 nonsense mutations generate trafficking defective NH2-terminally truncated channels by the reinitiation of translation.
P2860
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P2860
Regulation of deactivation by an amino terminal domain in human ether-à-go-go-related gene potassium channels.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Regulation of deactivation by ...... lated gene potassium channels.
@ast
Regulation of deactivation by ...... lated gene potassium channels.
@en
type
label
Regulation of deactivation by ...... lated gene potassium channels.
@ast
Regulation of deactivation by ...... lated gene potassium channels.
@en
prefLabel
Regulation of deactivation by ...... lated gene potassium channels.
@ast
Regulation of deactivation by ...... lated gene potassium channels.
@en
P2093
P2860
P356
P1476
Regulation of deactivation by ...... lated gene potassium channels.
@en
P2093
A M Zappia
G A Robertson
M C Trudeau
P2860
P304
P356
10.1085/JGP.112.5.637
P577
1998-11-01T00:00:00Z