Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)
about
The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporterManaging bile acid diarrhoeaBile acid transporters in health and diseaseBile acid transportersApical sodium dependent bile acid transporter (ASBT, SLC10A2): a potential prodrug targetMembrane topology of human ASBT (SLC10A2) determined by dual label epitope insertion scanning mutagenesis. New evidence for seven transmembrane domainsFood, fibre, bile acids and the pelvic floor: An integrated low risk low cost approach to managing irritable bowel syndromeSLC transporters as therapeutic targets: emerging opportunitiesFXR signaling in the enterohepatic systemCrystal structure of a bacterial homologue of the bile acid sodium symporter ASBTMutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasisAbsence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorptionHuman apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alphaRole of the intestinal bile acid transporters in bile acid and drug dispositionMonogenic dyslipidemias: window on determinants of plasma lipoprotein metabolismThe role of AP-1 in the transcriptional regulation of the rat apical sodium-dependent bile acid transporterA variant of the SLC10A2 gene encoding the apical sodium-dependent bile acid transporter is a risk factor for gallstone disease.In vivo performance of a novel fluorinated magnetic resonance imaging agent for functional analysis of bile acid transportXenobiotic, bile acid, and cholesterol transporters: function and regulation.Analysis of ileal sodium/bile acid cotransporter and related nuclear receptor genes in a family with multiple cases of idiopathic bile acid malabsorptionIdentification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer.Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism.Synthesis and in vitro evaluation of potential sustained release prodrugs via targeting ASBTDefining primary bile acid diarrhea: making the diagnosis and recognizing the disorder.Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition.Cholesterol modulates human intestinal sodium-dependent bile acid transporter.The ileal lipid binding protein is required for efficient absorption and transport of bile acids in the distal portion of the murine small intestine.Importance of uncharged polar residues and proline in the proximal two-thirds (Pro107-Ser128) of the highly conserved region of mouse ileal Na+-dependent bile acid transporter, Slc10a2, in transport activity and cellular expression.Deciphering the nuclear bile acid receptor FXR paradigm.FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption.A Klothoβ variant mediates protein stability and associates with colon transit in irritable bowel syndrome with diarrhea.Functional characterization of genetic variants in the apical sodium-dependent bile acid transporter (ASBT; SLC10A2).Intestinal transport and metabolism of bile acidsBiliary lipid composition in idiopathic bile acid malabsorption.Genetics of familial intrahepatic cholestasis syndromes.Molecular mechanisms of altered bile acid homeostasis in organic solute transporter-alpha knockout mice.Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor.Impact of Inhibiting Ileal Apical versus Basolateral Bile Acid Transport on Cholesterol Metabolism and Atherosclerosis in Mice.Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis.Cholesterol dependent downregulation of mouse and human apical sodium dependent bile acid transporter (ASBT) gene expression: molecular mechanism and physiological consequences.
P2860
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P2860
Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)
description
1997 nî lūn-bûn
@nan
1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Primary bile acid malabsorptio ...... cid transporter gene (SLC10A2)
@ast
Primary bile acid malabsorptio ...... cid transporter gene (SLC10A2)
@en
Primary bile acid malabsorptio ...... cid transporter gene (SLC10A2)
@en-gb
Primary bile acid malabsorptio ...... cid transporter gene (SLC10A2)
@nl
type
label
Primary bile acid malabsorptio ...... cid transporter gene (SLC10A2)
@ast
Primary bile acid malabsorptio ...... cid transporter gene (SLC10A2)
@en
Primary bile acid malabsorptio ...... cid transporter gene (SLC10A2)
@en-gb
Primary bile acid malabsorptio ...... cid transporter gene (SLC10A2)
@nl
prefLabel
Primary bile acid malabsorptio ...... cid transporter gene (SLC10A2)
@ast
Primary bile acid malabsorptio ...... cid transporter gene (SLC10A2)
@en
Primary bile acid malabsorptio ...... cid transporter gene (SLC10A2)
@en-gb
Primary bile acid malabsorptio ...... cid transporter gene (SLC10A2)
@nl
P2093
P2860
P356
P1476
Primary bile acid malabsorptio ...... cid transporter gene (SLC10A2)
@en
P2093
P2860
P304
P356
10.1172/JCI119355
P407
P50
P577
1997-04-01T00:00:00Z