The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development
about
Molecular mechanism of the Syk activation switchThe B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptorStructure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory MechanismForce-dependent calcium signaling and its pathway of human neutrophils on P-selectin in flowTULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of SykEndosomal trafficking of the ligated FcvarepsilonRI receptor.SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering.The autoinhibitory C-terminal SH2 domain of phospholipase C-γ2 stabilizes B cell receptor signalosome assembly.Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases.Arginine methylation of the B cell antigen receptor promotes differentiation.Global phosphoproteomics of activated B cells using complementary metal ion functionalized soluble nanopolymers.Complex phosphorylation dynamics control the composition of the Syk interactome in B cells.Tyrosines in the carboxyl terminus regulate Syk kinase activity and functionIdentification of CMTM7 as a transmembrane linker of BLNK and the B-cell receptorMast cell signaling: the role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participantsProteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrapRegulation and function of syk tyrosine kinase in mast cell signaling and beyond.Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulationDeficient synthesis of class-switched, HIV-neutralizing antibodies to the CD4 binding site and correction by electrophilic gp120 immunogen.The SYK tyrosine kinase: a crucial player in diverse biological functions.Spleen tyrosine kinase (Syk)-dependent calcium signals mediate efficient CpG-induced exocytosis of tumor necrosis factor α (TNFα) in innate immune cells.Rational combined targeting of phosphodiesterase 4B and SYK in DLBCLSyk and pTyr'd: Signaling through the B cell antigen receptorMechanism and regulatory function of CpG signaling via scavenger receptor B1 in primary B cells.The alphabeta T cell receptor is an anisotropic mechanosensor.Critical signal transduction pathways in CLL.B-lymphocyte calcium influx.The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system.B-cell receptor signaling inhibitors for treatment of autoimmune inflammatory diseases and B-cell malignancies.Promising therapies for the treatment of chronic lymphocytic leukemia.Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice.A spleen tyrosine kinase inhibitor reduces the severity of established glomerulonephritis.The lymphoma-associated fusion tyrosine kinase ITK-SYK requires pleckstrin homology domain-mediated membrane localization for activation and cellular transformation.Phosphorylation impact on Spleen Tyrosine kinase conformation by Surface Enhanced Raman Spectroscopy.Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70.Internalization of B cell receptors in human EU12 μHC⁺ immature B cells specifically alters downstream signaling events.Heterogeneous expression of Src tyrosine kinases Lyn, Fyn and Syk in classical Hodgkin lymphoma: prognostic implications.Inducible expression of hyperactive Syk in B cells activates Blimp-1-dependent terminal differentiation.Unperturbed Immune Function despite Mutation of C-Terminal Tyrosines in Syk Previously Implicated in Signaling and Activity Regulation.
P2860
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P2860
The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The kinase Syk as an adaptor c ...... nalling and B-cell development
@ast
The kinase Syk as an adaptor c ...... nalling and B-cell development
@en
The kinase Syk as an adaptor c ...... nalling and B-cell development
@en-gb
The kinase Syk as an adaptor c ...... nalling and B-cell development
@nl
type
label
The kinase Syk as an adaptor c ...... nalling and B-cell development
@ast
The kinase Syk as an adaptor c ...... nalling and B-cell development
@en
The kinase Syk as an adaptor c ...... nalling and B-cell development
@en-gb
The kinase Syk as an adaptor c ...... nalling and B-cell development
@nl
prefLabel
The kinase Syk as an adaptor c ...... nalling and B-cell development
@ast
The kinase Syk as an adaptor c ...... nalling and B-cell development
@en
The kinase Syk as an adaptor c ...... nalling and B-cell development
@en-gb
The kinase Syk as an adaptor c ...... nalling and B-cell development
@nl
P2093
P2860
P356
P1433
P1476
The kinase Syk as an adaptor c ...... nalling and B-cell development
@en
P2093
Elias Hobeika
Gleb Turchinovich
Michael Reth
P2860
P304
P356
10.1038/EMBOJ.2008.62
P407
P577
2008-05-07T00:00:00Z