Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
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The Syk tyrosine kinase suppresses malignant growth of human breast cancer cellsCoordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeletonGerminal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activationThe kinase Syk as an adaptor controlling sustained calcium signalling and B-cell developmentIdentification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activationLatent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinasesPositive and negative regulation of T-cell activation through kinases and phosphatasesImmunological function in mice lacking the Rac-related GTPase RhoGDistinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor functionDifferential effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)-associated p62Activation of the Syk tyrosine kinase is insufficient for downstream signal transduction in B lymphocytes.Targeting Syk in Autoimmune Rheumatic DiseasesFunctional roles of Syk in macrophage-mediated inflammatory responsesDevelopment of the mammalian lymphatic vasculatureInflammation and vascular injury: basic discovery to drug developmentSignal transduction in the chronic leukemias: implications for targeted therapiesSyk-mediated translocation of PI3Kdelta to the leading edge controls lamellipodium formation and migration of leukocytesStress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease.Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling.Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activationTyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in plateletsAKT induces transcriptional activity of PU.1 through phosphorylation-mediated modifications within its transactivation domainInteraction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxinBLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteinsPhosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor functionTyrosine phosphorylation and translocation of LAT in plateletsSLP76 and SLP65: complex regulation of signalling in lymphocytes and beyondThe non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinasesRegulation of B-1 cell activation and its autoantibody production by Lyn kinase-regulated signallingsSyk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosisPhosphorylation of Syk activation loop tyrosines is essential for Syk function. An in vivo study using a specific anti-Syk activation loop phosphotyrosine antibodyThe Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagenIntegrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifsThe Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signalingThe Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulationRegulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cellsSyk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption
P2860
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P248
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P2860
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
description
1995 nî lūn-bûn
@nan
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Perinatal lethality and blocke ...... acking the tyrosine kinase Syk
@ast
Perinatal lethality and blocke ...... acking the tyrosine kinase Syk
@en
Perinatal lethality and blocke ...... acking the tyrosine kinase Syk
@en-gb
Perinatal lethality and blocke ...... acking the tyrosine kinase Syk
@nl
type
label
Perinatal lethality and blocke ...... acking the tyrosine kinase Syk
@ast
Perinatal lethality and blocke ...... acking the tyrosine kinase Syk
@en
Perinatal lethality and blocke ...... acking the tyrosine kinase Syk
@en-gb
Perinatal lethality and blocke ...... acking the tyrosine kinase Syk
@nl
prefLabel
Perinatal lethality and blocke ...... acking the tyrosine kinase Syk
@ast
Perinatal lethality and blocke ...... acking the tyrosine kinase Syk
@en
Perinatal lethality and blocke ...... acking the tyrosine kinase Syk
@en-gb
Perinatal lethality and blocke ...... acking the tyrosine kinase Syk
@nl
P2093
P921
P3181
P356
P1433
P1476
Perinatal lethality and blocke ...... acking the tyrosine kinase Syk
@en
P2093
M T Furlong
O Williams
P S Costello
P2888
P304
P3181
P356
10.1038/378298A0
P407
P577
1995-11-01T00:00:00Z
P6179
1011405814