Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.
about
Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytesPoly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string searchSmad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formationSmad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesionThe Axin1 scaffold protein promotes formation of a degradation complex for c-MycWnt/beta-catenin signaling and small molecule inhibitorsSUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stabilityArkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradationAxin and GSK3- control Smad3 protein stability and modulate TGF- signalingSignaling in Fibrosis: TGF-β, WNT, and YAP/TAZ ConvergeKey role for ubiquitin protein modification in TGFβ signal transductionRegulation of TGF-β Superfamily Signaling by SMAD Mono-UbiquitinationThe role of targeted protein degradation in early neural developmentEmerging roles of Axin in cerebral cortical developmentGeneration of Axin1 conditional mutant miceAxin2 regulates chondrocyte maturation and axial skeletal developmentProtein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signalingDisordered proteinaceous machinesA decade and a half of protein intrinsic disorder: biology still waits for physicsUnexpected activities of Smad7 in Xenopus mesodermal and neural inductionUnderstanding protein non-folding.The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2)Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover.Human Sarcoma growth is sensitive to small-molecule mediated AXIN stabilization.Mechanisms of the epithelial-mesenchymal transition by TGF-betaThe regulation of TGF-β/SMAD signaling by protein deubiquitination.Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expressionMultiple Arkadia/RNF111 structures coordinate its Polycomb body association and transcriptional control.Intrinsic disorder in scaffold proteins: getting more from lessTransforming growth factor-β and the hallmarks of cancer.Enhancement of TGF-β signaling responses by the E3 ubiquitin ligase Arkadia provides tumor suppression in colorectal cancer.Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferationImpaired neural development caused by inducible expression of Axin in transgenic mice.Lithium Attenuates TGF-β(1)-Induced Fibroblasts to Myofibroblasts Transition in Bronchial Fibroblasts Derived from Asthmatic Patients.Multifaceted signaling regulators of chondrogenesis: Implications in cartilage regeneration and tissue engineeringThe four and a half LIM-only protein 2 (FHL2) activates transforming growth factor β (TGF-β) signaling by regulating ubiquitination of the E3 ligase Arkadia.SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells.Transforming growth factor-beta signaling and ubiquitinators in cancer.Axin1 and Axin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways.
P2860
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P2860
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.
description
2006 nî lūn-bûn
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2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Axin is a scaffold protein in ...... egradation of Smad7 by Arkadia
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Axin is a scaffold protein in ...... gradation of Smad7 by Arkadia.
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Axin is a scaffold protein in ...... gradation of Smad7 by Arkadia.
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Axin is a scaffold protein in ...... gradation of Smad7 by Arkadia.
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Axin is a scaffold protein in ...... egradation of Smad7 by Arkadia
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Axin is a scaffold protein in ...... gradation of Smad7 by Arkadia.
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Axin is a scaffold protein in ...... gradation of Smad7 by Arkadia.
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Axin is a scaffold protein in ...... gradation of Smad7 by Arkadia.
@en-gb
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Axin is a scaffold protein in ...... egradation of Smad7 by Arkadia
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Axin is a scaffold protein in ...... gradation of Smad7 by Arkadia.
@ast
Axin is a scaffold protein in ...... gradation of Smad7 by Arkadia.
@en
Axin is a scaffold protein in ...... gradation of Smad7 by Arkadia.
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P2093
P2860
P921
P3181
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Axin is a scaffold protein in ...... gradation of Smad7 by Arkadia.
@en
P2093
Hongliang Rui
Jiahuai Han
Jifeng Wang
Mingliang Chen
Sheng-Cai Lin
Shuyong Lin
Siu Chiu Chan
Suping Zhang
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7601057
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P577
2006-04-06T00:00:00Z